Triglyceride-rich lipoprotein abnormalities in CAPD-treated patients

R. Llopart, T. Doñate, J. A. Oliva, M. Rodá, F. Rousaud, F. Gonzalez-Sastre, J. Pedreño, J. Ordoñez-Llanos

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In the present study intermediate-density lipoproteins (IDL) and very-low-density lipoproteins (VLDL) composition, structure, and mass were analysed in fasting uraemic patients on continuous ambulatory peritoneal dialysis (CAPD) (n= 12) and on haemodialysis (HD) (n = 15), and in 15 healthy volunteers. All the groups were matched for sex, age, and time on dialysis. Both groups of patients had elevated very-low-density lipoprotein levels, CAPD patients four and HD group three times that of control. We found a fourfold and a twofold increase in the concentration of IDL cholesterol in theCAPD and HD group respectively when they were compared with the control group. Both groups of patients present an increased VLDL mass. The CAPD group showed a four-fold increase in IDL mass compared with the control group, which indicateda preponderance of large size and suggested that defective IDL clearance was involved. The IDL composition of the CAPD patients was significantly different from that of the HD patients: a twofold increase in IDL mass was observed in the CAPD patients if compared with HD patients. We report new data concerning the metabolism of triglyceride-rich lipoproteins inCAPD treated patients, which confirm the adverse effect of CAPD on serum lipids. © 1995 European Dialysis and Transplant Association-European Renal Association.
Idioma originalInglés
Páginas (desde-hasta)537-540
PublicaciónNephrology Dialysis Transplantation
EstadoPublicada - 1 ene 1995


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