Transcriptomic risk scores for attention deficit/hyperactivity disorder

Judit Cabana-Domínguez, Natalia Llonga, Lorena Arribas, Sílvia Alemany, L Vilar-Ribó, Ditte Demontis, Christian Fadeuilhe, Montserrat Corrales, Vanesa Richarte, Anders D. Børglum, Josep Antoni Ramos-Quiroga, María Soler Artigas, Marta Ribasés Haro

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

1 Cita (Scopus)

Resumen

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder. We performed a transcriptome-wide association study (TWAS) using the latest genome-wide association study (GWAS) meta-analysis, in 38,691 individuals with ADHD and 186,843 controls, and 14 gene-expression reference panels across multiple brain tissues and whole blood. Based on TWAS results, we selected subsets of genes and constructed transcriptomic risk scores (TRSs) for the disorder in peripheral blood mononuclear cells of individuals with ADHD and controls. We found evidence of association between ADHD and TRSs constructed using expression profiles from multiple brain areas, with individuals with ADHD carrying a higher burden of TRSs than controls. TRSs were uncorrelated with the polygenic risk score (PRS) for ADHD and, in combination with PRS, improved significantly the proportion of variance explained over the PRS-only model. These results support the complementary predictive potential of genetic and transcriptomic profiles in blood and underscore the potential utility of gene expression for risk prediction and deeper insight in molecular mechanisms underlying ADHD.
Idioma originalInglés
Páginas (desde-hasta)3493-3502
Número de páginas10
PublicaciónMolecular Psychiatry (Print)
Volumen28
DOI
EstadoPublicada - 2023

Huella

Profundice en los temas de investigación de 'Transcriptomic risk scores for attention deficit/hyperactivity disorder'. En conjunto forman una huella única.

Citar esto