The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains

Keyphrases

• Alpha-synuclein (α-syn) 100%
• Aromatic Compounds 100%
• Seeded Polymerization 100%
• Neurodegenerative Diseases 50%
• Intracellular Accumulation 50%
• Parkinson's Disease 50%
• Amyloid Fibrils 50%
• Dopaminergic Neurons 50%
• Protein Components 50%
• Lewy 50%
• Lewy Bodies 50%
• Substantia Nigra 50%
• Incubation 50%
• Synucleinopathy 50%
• Salt Concentration 50%
• Amyloid Structure 50%
• Intrinsically Disordered Proteins 50%
• Fibril Disaggregation 50%
• Lewy Neurites 50%
• Intraneuronal 50%
• Strain Specificity 50%
• Hit Compound 50%
• Conformational Strain 50%
• Small Aromatic Molecules 50%
• Pathological Traits 50%

Biochemistry, Genetics and Molecular Biology

• Synuclein 100%
• Amyloid Protein 100%
• Conformation 33%
• Intrinsically Disordered Protein 33%
• Dopaminergic 33%