The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

Matthieu Legrand; Ashish K. Khanna; Marlies Ostermann; Yuki Kotani; Ricard Ferrer; Massimo Girardis; Marc Leone; Gennaro DePascale; Peter Pickkers; Pierre Tissieres; Filippo Annoni; Katarzyna Kotfis; Giovanni Landoni; Alexander Zarbock; Patrick M. Wieruszewski; Daniel De Backer; Jean-Louis Vincent; Rinaldo Bellomo

doi:10.1186/s13054-024-05123-7

The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

Matthieu Legrand, Ashish K. Khanna, Marlies Ostermann, Yuki Kotani, Ricard Ferrer, Massimo Girardis, Marc Leone, Gennaro DePascale, Peter Pickkers, Pierre Tissieres, Filippo Annoni, Katarzyna Kotfis, Giovanni Landoni, Alexander Zarbock, Patrick M. Wieruszewski, Daniel De Backer, Jean-Louis Vincent, Rinaldo Bellomo

Departamento de Medicina

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

2 Citas (Scopus)

Resumen

Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.

Idioma original	Inglés
Publicación	Critical Care
Volumen	28
DOI	https://doi.org/10.1186/s13054-024-05123-7
Estado	Publicada - 2024

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Legrand, M., Khanna, A. K., Ostermann, M., Kotani, Y., Ferrer, R., Girardis, M., Leone, M., DePascale, G., Pickkers, P., Tissieres, P., Annoni, F., Kotfis, K., Landoni, G., Zarbock, A., Wieruszewski, P. M., De Backer, D., Vincent, J.-L., & Bellomo, R. (2024). The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II. Critical Care, 28. https://doi.org/10.1186/s13054-024-05123-7

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title = "The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II",

abstract = "Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.",

author = "Matthieu Legrand and Khanna, {Ashish K.} and Marlies Ostermann and Yuki Kotani and Ricard Ferrer and Massimo Girardis and Marc Leone and Gennaro DePascale and Peter Pickkers and Pierre Tissieres and Filippo Annoni and Katarzyna Kotfis and Giovanni Landoni and Alexander Zarbock and Wieruszewski, {Patrick M.} and {De Backer}, Daniel and Jean-Louis Vincent and Rinaldo Bellomo",

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doi = "10.1186/s13054-024-05123-7",

language = "English",

volume = "28",

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Legrand, M, Khanna, AK, Ostermann, M, Kotani, Y, Ferrer, R, Girardis, M, Leone, M, DePascale, G, Pickkers, P, Tissieres, P, Annoni, F, Kotfis, K, Landoni, G, Zarbock, A, Wieruszewski, PM, De Backer, D, Vincent, J-L & Bellomo, R 2024, 'The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II', Critical Care, vol. 28. https://doi.org/10.1186/s13054-024-05123-7

TY - JOUR

T1 - The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

AU - Legrand, Matthieu

AU - Khanna, Ashish K.

AU - Ostermann, Marlies

AU - Kotani, Yuki

AU - Ferrer, Ricard

AU - Girardis, Massimo

AU - Leone, Marc

AU - DePascale, Gennaro

AU - Pickkers, Peter

AU - Tissieres, Pierre

AU - Annoni, Filippo

AU - Kotfis, Katarzyna

AU - Landoni, Giovanni

AU - Zarbock, Alexander

AU - Wieruszewski, Patrick M.

AU - De Backer, Daniel

AU - Vincent, Jean-Louis

AU - Bellomo, Rinaldo

PY - 2024

Y1 - 2024

N2 - Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.

AB - Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.

U2 - 10.1186/s13054-024-05123-7

DO - 10.1186/s13054-024-05123-7

M3 - Article

C2 - 39593182

SN - 1466-609X

VL - 28

JO - Critical Care

JF - Critical Care

ER -

The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

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