The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P. J. Cardona; A. Cooper; M. Luquín; A. Ariza; F. Filipo; I. M. Orme; V. Ausina

doi:10.1046/j.1365-3083.1999.00522.x

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P. J. Cardona, A. Cooper, M. Luquín, A. Ariza, F. Filipo, I. M. Orme, V. Ausina

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

57 Citas (Scopus)

Resumen

The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

Idioma original	Inglés
Páginas (desde-hasta)	362-366
Publicación	Scandinavian Journal of Immunology
Volumen	49
DOI	https://doi.org/10.1046/j.1365-3083.1999.00522.x
Estado	Publicada - 28 abr 1999

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10.1046/j.1365-3083.1999.00522.x

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@article{468db72db32541dabb3a10c2fc3865d0,

title = "The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity",

abstract = "The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.",

author = "Cardona, {P. J.} and A. Cooper and M. Luqu{\'i}n and A. Ariza and F. Filipo and Orme, {I. M.} and V. Ausina",

year = "1999",

month = apr,

day = "28",

doi = "10.1046/j.1365-3083.1999.00522.x",

language = "English",

volume = "49",

pages = "362--366",

journal = "Scandinavian Journal of Immunology",

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The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity. / Cardona, P. J.; Cooper, A.; Luquín, M. et al.
En: Scandinavian Journal of Immunology, Vol. 49, 28.04.1999, p. 362-366.

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

TY - JOUR

T1 - The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

AU - Cardona, P. J.

AU - Cooper, A.

AU - Luquín, M.

AU - Ariza, A.

AU - Filipo, F.

AU - Orme, I. M.

AU - Ausina, V.

PY - 1999/4/28

Y1 - 1999/4/28

N2 - The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

AB - The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-γ response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

U2 - 10.1046/j.1365-3083.1999.00522.x

DO - 10.1046/j.1365-3083.1999.00522.x

M3 - Article

SN - 0300-9475

VL - 49

SP - 362

EP - 366

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

ER -

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

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