The increasing impact of lethal mutagenesis of viruses

Celia Perales, Isabel Gallego, Ana Isabel De Ávila, María Eugenia Soria, Josep Gregori, Josep Quer, Esteban Domingo

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

31 Citas (Scopus)

Resumen

Selection of viral mutants resistant to compounds used in therapy is a major determinant of treatment failure, a problem akin to antibiotic resistance in bacteria. In this scenario, mutagenic base and nucleoside analogs have entered the picture because they increase the mutation rate of viral populations to levels incompatible with their survival. This antiviral strategy is termed lethal mutagenesis. It has found a major impulse with the observation that some antiviral agents, which initially were considered only inhibitors of virus multiplication, may in effect exert part of their antiviral activity through mutagenesis. Here, we review the conceptual basis of lethal mutagenesis, the evidence of virus extinction through mutagenic nucleotide analogs and prospects for application in antiviral designs.
Idioma originalInglés
Páginas (desde-hasta)1645-1657
Número de páginas13
PublicaciónFuture Medicinal Chemistry
Volumen11
N.º13
DOI
EstadoPublicada - jul 2019

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