TY - CHAP
T1 - The Impact of Rapid Evolution of Hepatitis Viruses
AU - Quer, J.
AU - Martell, M.
AU - Rodriguez, F.
AU - Bosch, A.
AU - Jardi, R.
AU - Buti, M.
AU - Esteban, J. I.
PY - 2008
Y1 - 2008
N2 - Hepatitis viruses comprise a group of very diverse pathogens that primarily infect the liver, but belong to very different virus families with very different replication strategies (hepatitis A virus (HAV) Picornaviridae, hepatitis B virus (HBV) Hepadnaviridae, hepatitis C virus (HCV) Flaviviridae, hepatitis delta virus (HDV) genus Deltavirus, not assigned to a family yet, and hepatitis E virus (HEV) Hepeviridae). All of them have in common a high genome plasticity, and have received special attention because of their worldwide distribution in human population, infecting hundreds of million people, causing either acute and/or chronic infections that in many cases lead to liver cirrhosis and hepatocellular carcinoma, which is one of the leading causes of death worldwide. The huge number of infected people all over the world is the best proof of how different replication and transmission strategies, with the common factor of variability, may succeed in terms of viral persistence.
AB - Hepatitis viruses comprise a group of very diverse pathogens that primarily infect the liver, but belong to very different virus families with very different replication strategies (hepatitis A virus (HAV) Picornaviridae, hepatitis B virus (HBV) Hepadnaviridae, hepatitis C virus (HCV) Flaviviridae, hepatitis delta virus (HDV) genus Deltavirus, not assigned to a family yet, and hepatitis E virus (HEV) Hepeviridae). All of them have in common a high genome plasticity, and have received special attention because of their worldwide distribution in human population, infecting hundreds of million people, causing either acute and/or chronic infections that in many cases lead to liver cirrhosis and hepatocellular carcinoma, which is one of the leading causes of death worldwide. The huge number of infected people all over the world is the best proof of how different replication and transmission strategies, with the common factor of variability, may succeed in terms of viral persistence.
KW - B e-antigen
KW - Dependent rna-polymerase
KW - Cellular immune-responses
KW - Core promoter region
KW - Open reading frame
KW - Fragment-length-polymorphism
KW - Complete nucleotide-sequence
KW - Naturally-occurring variants
KW - Liver-transplant recipients
KW - T-lymphocyte responses
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=uab_pure&SrcAuth=WosAPI&KeyUT=WOS:000316607300017&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/B978-0-12-374153-0.00015-1
DO - 10.1016/B978-0-12-374153-0.00015-1
M3 - Chapter
SN - 978-0-12-374153-0
SP - 303
EP - 349
BT - Origin And Evolution Of Viruses, 2nd Edition
A2 - Domingo, E
A2 - Parrish, CR
A2 - Holland, JJ
PB - Elsevier
ER -
