The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Keyphrases

• N-methyl-D-aspartate Receptor (NMDAR) 100%
• Primary Cortical Neurons 100%
• Receptor Signaling 100%
• Phosphorylated tau 100%
• PrPC 100%
• Cellular Prion Protein 100%
• Alzheimer's Disease 17%
• Alzheimer's Disease Model 11%
• Mitogen-activated Protein Kinase 11%
• Axonal Transport 11%
• Receptor-mediated 11%
• Neuronal Death 5%
• Pathophysiology 5%
• Transgenic Mouse Model 5%
• Indiana 5%
• Microglia 5%
• Current Treatment 5%
• Mouse Brain 5%
• Transgenic Mice 5%
• Neuronal Primary Cultures 5%
• Direct Interaction 5%
• Signaling Cascades 5%
• Prion Protein 5%
• Neurotoxicity 5%
• Primary Culture 5%
• Macromolecular Complex 5%
• Cortical Neurons 5%
• Primary Neurons 5%
• Complex Formation 5%
• Mediating Effect 5%
• Proximity Ligation Assay 5%
• Label-free Assay 5%
• Heterologous System 5%
• Bioluminescence Resonance Energy Transfer 5%
• Mouse Primary Neuron 5%
• Negative Modulation 5%
• Human Amyloid Precursor Protein 5%
• NMDA Signaling 5%
• Isolation Device 5%
• Axon Isolation 5%

Neuroscience

• Aspartic Acid 100%
• Prion Protein 100%
• Receptor 100%
• Alzheimer's Disease 45%
• N-Methyl-D-Aspartic Acid 36%
• Mitogen-Activated Protein Kinase 18%
• Primary Culture 18%
• Axoplasmic Transport 18%
• Neuronal Cell Death 9%
• Cyclic Adenosine Monophosphate 9%
• Neurotoxicity 9%
• Amyloid Precursor Protein 9%
• Axon 9%
• Energy Transfer 9%
• NMDA Receptor 9%
• Complex Formation 9%
• Bioluminescence 9%

Biochemistry, Genetics and Molecular Biology

• Prion Protein 100%
• Aspartic Acid 100%
• N-Methyl-D-Aspartic Acid 40%
• Tau 20%
• Primary Culture 20%
• Nerve Fiber Transport 20%
• Mitogen-Activated Protein Kinase 20%
• Transgenic Mouse 10%
• NMDA Receptor 10%
• Axon 10%
• Complex Formation 10%
• Energy Transfer 10%
• Cyclic Adenosine Monophosphate 10%
• Amyloid Precursor Protein 10%
• Transgenic Organism 10%
• Bioluminescence 10%