TY - JOUR
T1 - The carbapenemase-producing Klebsiella pneumoniae population is distinct and more clonal than the carbapenem-susceptible population
AU - Esteban-Cantos, Andrés
AU - Aracil, Belén
AU - Bautista, Verónica
AU - Ortega, Adriana
AU - Lara, Noelia
AU - Saez, David
AU - Fernández-Romero, Sara
AU - Pérez-Vázquez, María
AU - Navarro, Ferran
AU - Grundmann, Hajo
AU - Campos, José
AU - Oteo, Jesús
AU - Alarcón, Teresa
AU - Barba, Isabel
AU - Cercenado, Emilia
AU - De Miguel, M. Antonia
AU - De Miguel, Dolores
AU - Fontanals, Dionisia
AU - Fleites, Ana M.
AU - Sánchez-Romero, Isabel
AU - Solís, Sonia
AU - Gimeno, Adelina
AU - Hernández, Juan Manuel
AU - Martínez-López, Jesús
AU - Alós, Juan Ignacio
AU - Arias, Marta
AU - Yagüe, Genoveva
AU - De Baranda, Caridad Sainz
AU - Cordón, Luz Albina
AU - Leiva, José
AU - Pérez-Moreno, Mar Olga
N1 - Publisher Copyright:
© 2017 American Society for Microbiology. All Rights Reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2017/4
Y1 - 2017/4
N2 - We studied in parallel the population structure of 90 carbapenemase-producing and 88 carbapenemase-susceptible Klebsiella pneumoniae isolates collected in 20 Spanish hospitals, in the context of the EuSCAPE project. Fourteen and 50 multilocus sequence types (MLSTs) were detected among the carbapenemase-producing and carbapenem-susceptible isolates, respectively. ST11 and ST15 clones were more frequent in the carbapenemase-producing group than in the carbapenemase-susceptible group (P < 0.0001). Among the members of the carbapenem-suceptible group, the cefotaxime-resistant population showed population parameters that differed between the populations of the wild-type strains and the carbapenemase producers.
AB - We studied in parallel the population structure of 90 carbapenemase-producing and 88 carbapenemase-susceptible Klebsiella pneumoniae isolates collected in 20 Spanish hospitals, in the context of the EuSCAPE project. Fourteen and 50 multilocus sequence types (MLSTs) were detected among the carbapenemase-producing and carbapenem-susceptible isolates, respectively. ST11 and ST15 clones were more frequent in the carbapenemase-producing group than in the carbapenemase-susceptible group (P < 0.0001). Among the members of the carbapenem-suceptible group, the cefotaxime-resistant population showed population parameters that differed between the populations of the wild-type strains and the carbapenemase producers.
KW - Carbapenem resistance
KW - Carbapenemases
KW - Klebsiella pneumoniae
KW - MLST
KW - Population structure
UR - http://www.scopus.com/inward/record.url?scp=85016967162&partnerID=8YFLogxK
U2 - 10.1128/AAC.02520-16
DO - 10.1128/AAC.02520-16
M3 - Article
C2 - 28137818
AN - SCOPUS:85016967162
SN - 0066-4804
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
M1 - e02520-16
ER -