Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages

Kevin Morales; Katia G. Samper; Quim Peña; Jordi Hernando; Julia Lorenzo; Antonio Rodríguez-Diéguez; Mercè Capdevila; Marta Figueredo; Òscar Palacios; Pau Bayón

doi:10.1021/acs.inorgchem.8b02854

Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages

Kevin Morales, Katia G. Samper, Quim Peña, Jordi Hernando, Julia Lorenzo, Antonio Rodríguez-Diéguez, Mercè Capdevila, Marta Figueredo, Òscar Palacios, Pau Bayón

Producción científica: Contribución a una revista › Artículo › Investigación

8 Citas (Scopus)

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© Copyright 2018 American Chemical Society. Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.

Idioma original	Inglés
Páginas (desde-hasta)	15517-15525
Publicación	INORGANIC CHEMISTRY
Volumen	57
DOI	https://doi.org/10.1021/acs.inorgchem.8b02854
Estado	Publicada - 17 dic 2018

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@article{21822d956d7f41aeb8060b9adcef2795,

title = "Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages",

abstract = "{\textcopyright} Copyright 2018 American Chemical Society. Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.",

author = "Kevin Morales and Samper, {Katia G.} and Quim Pe{\~n}a and Jordi Hernando and Julia Lorenzo and Antonio Rodr{\'i}guez-Di{\'e}guez and Merc{\`e} Capdevila and Marta Figueredo and {\`O}scar Palacios and Pau Bay{\'o}n",

year = "2018",

month = dec,

day = "17",

doi = "10.1021/acs.inorgchem.8b02854",

language = "English",

volume = "57",

pages = "15517--15525",

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TY - JOUR

T1 - Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages

AU - Morales, Kevin

AU - Samper, Katia G.

AU - Peña, Quim

AU - Hernando, Jordi

AU - Lorenzo, Julia

AU - Rodríguez-Diéguez, Antonio

AU - Capdevila, Mercè

AU - Figueredo, Marta

AU - Palacios, Òscar

AU - Bayón, Pau

PY - 2018/12/17

Y1 - 2018/12/17

N2 - © Copyright 2018 American Chemical Society. Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.

AB - © Copyright 2018 American Chemical Society. Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.

U2 - 10.1021/acs.inorgchem.8b02854

DO - 10.1021/acs.inorgchem.8b02854

M3 - Article

C2 - 30495945

SN - 0020-1669

VL - 57

SP - 15517

EP - 15525

JO - INORGANIC CHEMISTRY

JF - INORGANIC CHEMISTRY

ER -

Squaramide-Based Pt(II) Complexes as Potential Oxygen-Regulated Light-Triggered Photocages

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