Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

Satish Rao, Saurabh Raj, Stefan Balint, Carlota Bardina Fons, Susana Campoy, Montserrat Llagostera, Dmitri Petrov

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Resumen

Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. © 2010 American Institute of Physics.
Idioma originalInglés
Número de artículo213701
PublicaciónApplied physics letters
Volumen96
DOI
EstadoPublicada - 24 may 2010

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