Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells

Keyphrases

• Transcription Factor 100%
• Testosterone 100%
• DU145 100%
• Dihydrotestosterone 100%
• Zinc Finger E-box Binding Homeobox 1 (ZEB1) 100%
• Steroidogenic Pathway 100%
• Prostate Cancer 60%
• Androgen Receptor Expression 60%
• Expression Level 40%
• Reductase 40%
• Aldo-keto Reductase Family 1 40%
• Cytochrome P450 (CYP450) 20%
• Quantitative PCR 20%
• Western Blotting 20%
• Subcellular Localization 20%
• Most Common Form 20%
• MRNA Level 20%
• Immunocytochemistry 20%
• Malignancy 20%
• Subfamily A 20%
• Protein Expression Level 20%
• Cell Culture Media 20%
• Prostate 20%
• Prostate Cancer Cell Lines 20%
• Androgen Synthesis 20%
• Androgen Production 20%
• Human Prostate Cancer Cells 20%
• Castration-resistant 20%
• Steroidogenic Acute Regulatory Protein (StAR) 20%
• Epithelial-mesenchymal Transition 20%
• Androgens 20%

Biochemistry, Genetics and Molecular Biology

• Transcription Factor ZEB1 100%
• Androgen Receptor 60%
• Reductase 40%
• Aldo-Keto Reductase 40%
• Oxidoreductase 40%
• Androgen Synthesis 40%
• Subcellular Localization 20%
• Quantitative Reverse Transcription Polymerase Chain Reaction 20%
• Western Blot 20%
• Enzyme 20%
• Cancer Cell 20%
• Immunocytochemistry 20%
• Transcription Factors 20%
• Cell Culture 20%
• Protein Expression Level 20%
• Mesenchymal-Epithelial Transition 20%
• mRNA Expression Level 20%
• Cytochrome P450 20%