TY - JOUR
T1 - Ruthenium-catalyzed asymmetric hydrogenation of N-(3,4-dihydro-2-naphthalenyl)-acetamide
AU - Sala, Xavier
AU - Serrano, Isabel
AU - Rodríguez, Montserrat
AU - Romero, Isabel
AU - Llobet, Antoni
AU - van Leeuwen, Piet W.N.M.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - The enantioselective hydrogenation of a challenging enamide (N-(3,4-dihydro-2-naphthalenyl)-acetamide, 1) bearing an endocyclic trisubstituted carbon-carbon double bond has been performed using cis-fac-Δ-[RuIICl{(R)-(bpea)}{(S)-(BINAP)}] BF4, cis-fac-Δ-(R)-(S)-3, as catalyst achieving good conversions and enantioselectivities up to 74%. Furthermore, the study of the influence of different reaction parameters during the hydrogenation reaction has been performed, showing a strong influence of the coordinating ability of the solvent on the reaction rate. © 2007 Elsevier B.V. All rights reserved.
AB - The enantioselective hydrogenation of a challenging enamide (N-(3,4-dihydro-2-naphthalenyl)-acetamide, 1) bearing an endocyclic trisubstituted carbon-carbon double bond has been performed using cis-fac-Δ-[RuIICl{(R)-(bpea)}{(S)-(BINAP)}] BF4, cis-fac-Δ-(R)-(S)-3, as catalyst achieving good conversions and enantioselectivities up to 74%. Furthermore, the study of the influence of different reaction parameters during the hydrogenation reaction has been performed, showing a strong influence of the coordinating ability of the solvent on the reaction rate. © 2007 Elsevier B.V. All rights reserved.
KW - Asymmetric catalysis
KW - Enamide hydrogenation
KW - Ruthenium
U2 - 10.1016/j.catcom.2007.05.030
DO - 10.1016/j.catcom.2007.05.030
M3 - Article
SN - 1566-7367
VL - 9
SP - 117
EP - 119
JO - Catalysis Communications
JF - Catalysis Communications
IS - 1
ER -