TY - JOUR
T1 - Role of Acinetobacter baumannii UmuD homologs in antibiotic resistance acquired through DNA damage-induced mutagenesis
AU - Aranda, Jesús
AU - López, Mario
AU - Leiva, Enoy
AU - Magán, Andrés
AU - Adler, Ben
AU - Bou, Germán
AU - Barbé, Jordi
PY - 2014/3/1
Y1 - 2014/3/1
N2 - The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S-0636-A1S-0637, A1S-1174-A1S-1173, and A1S-1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that of the wild-type parental strain. However, all mutants, and especially the umuDAb mutant, were less able to acquire resistance to rifampin and streptomycin through the activities of their error-prone DNA polymerases. Furthermore, in the A. baumannii mutant defective in the umuDAb gene, the spectrum of mutations included a dramatic reduction in the frequency of transition mutations, the mutagenic signature of the DNA polymerase V encoded by umuDC. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
AB - The role of Acinetobacter baumannii ATCC 17978 UmuDC homologs A1S-0636-A1S-0637, A1S-1174-A1S-1173, and A1S-1389 (UmuDAb) in antibiotic resistance acquired through UV-induced mutagenesis was evaluated. Neither the growth rate nor the UV-related survival of any of the three mutants was significantly different from that of the wild-type parental strain. However, all mutants, and especially the umuDAb mutant, were less able to acquire resistance to rifampin and streptomycin through the activities of their error-prone DNA polymerases. Furthermore, in the A. baumannii mutant defective in the umuDAb gene, the spectrum of mutations included a dramatic reduction in the frequency of transition mutations, the mutagenic signature of the DNA polymerase V encoded by umuDC. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
U2 - 10.1128/AAC.02346-13
DO - 10.1128/AAC.02346-13
M3 - Article
SN - 0066-4804
VL - 58
SP - 1771
EP - 1773
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
ER -