Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease

José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, D. Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

15 Citas (Scopus)

Resumen

Copyright © 2016, American Society for Microbiology. All Rights Reserved. Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting.
Idioma originalInglés
Páginas (desde-hasta)2564-2566
PublicaciónAntimicrobial Agents and Chemotherapy
Volumen60
N.º4
DOI
EstadoPublicada - 1 abr 2016

Huella

Profundice en los temas de investigación de 'Removal of dolutegravir by hemodialysis in HIV-Infected patients with end-stage renal disease'. En conjunto forman una huella única.

Citar esto