Purifying selection maintains highly conserved noncoding sequences in Drosophila

Biochemistry, Genetics and Molecular Biology

• Negative Selection (Natural Selection) 100%
• Coding Region 66%
• Comparative Genomics 33%
• Regulatory Sequence 33%
• Population Genetics 33%
• Human Genome 33%
• Molecular Evolution 33%
• Mutation Rate 33%
• Drosophila Melanogaster 33%
• Allele 33%
• RNA Gene 33%
• Non-Coding RNA 33%
• Point Mutation 33%
• Intergenic Region 33%
• Noncoding DNA 33%
• Insect Genome 33%
• Genomics 33%

Keyphrases

• Drosophilidae 100%
• Purifying Selection 100%
• Conserved Non-coding Elements 100%
• Cold Spot 33%
• Coding Region 16%
• Positive Selection 16%
• Metazoan 16%
• Spacer Region 16%
• Human Genome 8%
• Molecular Evolution 8%
• Divergence 8%
• Cis-regulatory Elements 8%
• Genomic Regions 8%
• Mutation Rate 8%
• Drosophila Melanogaster 8%
• Polymorphism 8%
• Point mutation 8%
• Non-protein 8%
• Comparative Genomics 8%
• Genomic Data 8%
• Evolutionary Process 8%
• Non-selective 8%
• Genome Project 8%
• Reliable Indicator 8%
• Recurrent Positive 8%
• 4-fold 8%
• Number of Sites 8%
• Population Genetic Data 8%
• Functional Significance 8%
• Derived Allele 8%
• Non-coding Gene 8%
• Sequence Evolution 8%
• Selection Coefficient 8%
• Intergenic 8%
• Non-coding DNA 8%
• Insect Genome 8%
• Constrained Sequences 8%