Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas.

J Rodon; AZ Mykytyn; G Cantero; IC Albulescu; BJ Bosch; A Brix; JC Audonnet; A Bensaid; J Vergara-Alert; BL Haagmans; J Segalés

doi:10.1186/s42522-022-00068-9

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas.

J Rodon, AZ Mykytyn, G Cantero, IC Albulescu, BJ Bosch, A Brix, JC Audonnet, A Bensaid, J Vergara-Alert, BL Haagmans, J Segalés

Departamento de Sanidad y Anatomía Animales

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

Resumen

Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.

Idioma original	Inglés
Páginas (desde-hasta)	12
Publicación	One health outlook
Volumen	4
N.º	1
DOI	https://doi.org/10.1186/s42522-022-00068-9
Estado	Publicada - dic 2022

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

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10.1186/s42522-022-00068-9

https://ddd.uab.cat/record/266211

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Citar esto

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abstract = "Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to na{\"i}ve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.",

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AU - Mykytyn, AZ

AU - Cantero, G

AU - Albulescu, IC

AU - Bosch, BJ

AU - Brix, A

AU - Audonnet, JC

AU - Bensaid, A

AU - Vergara-Alert, J

AU - Haagmans, BL

AU - Segalés, J

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