Preparation of enantiomers of 1-(1-naphthyl)-2,2-dimethylpropylamine and their behaviour as chiral solvating agents: Study of diastereochemic association by Job's plots and intermolecular NOE measurements

A. Port, A. Virgili, A. Alvarez Alvarez-Larena, J. F. Piniella

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31 Citas (Scopus)

Resumen

Enantiomers of 1-(1-naphthyl)-2,2-dimethylpropylamine have been obtained and considered as chiral solvating agents against several compounds. The formed complexes have been studied with the aid of the nuclear Overhauser effect and its stoichiometry by the method of continuous variations. Two diastereoisomeric complexes present similar geometry of association by π-π-stacking of the aromatic rings and by hydrogen bonding of the functional groups. © 2000 Elsevier Science Ltd.
Idioma originalInglés
Páginas (desde-hasta)3747-3757
PublicaciónTetrahedron Asymmetry
Volumen11
N.º18
DOI
EstadoPublicada - 22 sept 2000

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