Preclinical studies with new pyrrolidine platinum(II) compounds

F. Sampedro; VWT W.T. Ruiz van Haperen; MA A. Izquierdo; M. Vicens; P. Santaló; M. Pueyo; M. Llagostera; E. Marcuello; L. De Andrés

doi:10.1016/0223-5234(96)88260-2

Preclinical studies with new pyrrolidine platinum(II) compounds

F. Sampedro, VWT W.T. Ruiz van Haperen, MA A. Izquierdo, M. Vicens, P. Santaló, M. Pueyo, M. Llagostera, E. Marcuello, L. De Andrés

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

8 Citas (Scopus)

Resumen

Four new platinum compounds containing different pyrrolidines as ligands are reported. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. In vitro tests using leukemia L1210 cells show growth inhibition by the new compounds within the range of cisplatin and carboplatin. In vivo tests using leukemia L1210 cells on male BDF1 show that these compounds are significantly active. © 1995 Elsevier, Paris.

Idioma original	Inglés
Páginas (desde-hasta)	497-501
Publicación	European Journal of Medicinal Chemistry
Volumen	30
N.º	6
DOI	https://doi.org/10.1016/0223-5234(96)88260-2
Estado	Publicada - 1 ene 1995

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Acceder al documento

10.1016/0223-5234(96)88260-2

Otros archivos y enlaces

https://www.scopus.com/pages/publications/0029043258

Citar esto

@article{ce6a315345904fea82d81dcd1f536985,

title = "Preclinical studies with new pyrrolidine platinum(II) compounds",

abstract = "Four new platinum compounds containing different pyrrolidines as ligands are reported. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. In vitro tests using leukemia L1210 cells show growth inhibition by the new compounds within the range of cisplatin and carboplatin. In vivo tests using leukemia L1210 cells on male BDF1 show that these compounds are significantly active. {\textcopyright} 1995 Elsevier, Paris.",

keywords = "antitumoral activity, cancer treatment, growth, inhibition, L1210 leukemia, platinum(II) compound, platinum(II)-DNA damage, pyrrolidine, viability",

author = "F. Sampedro and \{Ruiz van Haperen\}, \{VWT W.T.\} and Izquierdo, \{MA A.\} and M. Vicens and P. Santal{\'o} and M. Pueyo and M. Llagostera and E. Marcuello and Andr{\'e}s, \{L. De\}",

year = "1995",

month = jan,

day = "1",

doi = "10.1016/0223-5234(96)88260-2",

language = "English",

volume = "30",

pages = "497--501",

number = "6",

}

TY - JOUR

T1 - Preclinical studies with new pyrrolidine platinum(II) compounds

AU - Sampedro, F.

AU - Ruiz van Haperen, VWT W.T.

AU - Izquierdo, MA A.

AU - Vicens, M.

AU - Santaló, P.

AU - Pueyo, M.

AU - Llagostera, M.

AU - Marcuello, E.

AU - Andrés, L. De

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Four new platinum compounds containing different pyrrolidines as ligands are reported. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. In vitro tests using leukemia L1210 cells show growth inhibition by the new compounds within the range of cisplatin and carboplatin. In vivo tests using leukemia L1210 cells on male BDF1 show that these compounds are significantly active. © 1995 Elsevier, Paris.

AB - Four new platinum compounds containing different pyrrolidines as ligands are reported. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. In vitro tests using leukemia L1210 cells show growth inhibition by the new compounds within the range of cisplatin and carboplatin. In vivo tests using leukemia L1210 cells on male BDF1 show that these compounds are significantly active. © 1995 Elsevier, Paris.

KW - antitumoral activity

KW - cancer treatment

KW - growth

KW - inhibition

KW - L1210 leukemia

KW - platinum(II) compound

KW - platinum(II)-DNA damage

KW - pyrrolidine

KW - viability

UR - https://www.scopus.com/pages/publications/0029043258

U2 - 10.1016/0223-5234(96)88260-2

DO - 10.1016/0223-5234(96)88260-2

M3 - Article

SN - 0223-5234

VL - 30

SP - 497

EP - 501

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 6

ER -

Preclinical studies with new pyrrolidine platinum(II) compounds

Resumen

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto