@article{e2272bee17e542afae2fa452491edd3f,
title = "Population pharmacokinetics of anidulafungin in critically ill patients",
abstract = "Copyright {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved. A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations suggested that patients with higher TBWs had less-extensive MIC coverage. Dosage escalation may be warranted in patients with high TBWs to ensure optimal drug exposures for treatment of Candida albicans and Candida glabrata infections.",
keywords = "Anidulafungin, Candida, Critical care unit, Monte Carlo simulation, Pharmacokinetics/pharmacodynamics",
author = "S. Luque and W. Hope and N. Campillo and R. Mu{\~n}oz-Berm{\'u}dez and L. Sorli and J. Barcel{\'o}-Vidal and E. Gonz{\'a}lez-Colominas and F. Alvarez-Lerma and Masclans, {J. R.} and M. Montero and Horcajada, {J. P.} and S. Graua",
note = "Copyright {\textcopyright} 2019 American Society for Microbiology.",
year = "2019",
month = jul,
doi = "10.1128/AAC.00378-19",
language = "English",
volume = "63",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "7",
}