Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments

Isabella Vainieri, Joanna Martin, Anna-Sophie Rommel, Philip Asherson, Tobias Banaschewski, Jan Buitelaar, Bru Cormand, Jennifer Crosbie, Stephen V. Faraone, Barbara Franke, Sandra K. Loo, Ana Miranda, Iris Manor, Robert D. Oades, Kirstin L. Purves, Josep Antoni Ramos-Quiroga, Marta Ribasés Haro, Herbert Roeyers, Aribert Rothenberger, Russell SchacharJoseph Sergeant, Hans-Christoph Steinhausen, Pieter J. Vuijk, Alysa E. Doyle, Jonna Kuntsi

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

6 Citas (Scopus)

Resumen

A recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE). The discovery GWAS included 19 099 ADHD cases and 34 194 control participants. The combined target sample included 845 people with ADHD (age: 8-40 years). RTV and CE were available from reaction time and response inhibition tasks. ADHD PRS were calculated from the GWAS using a leave-one-study-out approach. Regression analyses were run to investigate whether ADHD PRS were associated with CE and RTV. Results across sites were combined via random effect meta-analyses. When combining the studies in meta-analyses, results were significant for RTV (R 2 = 0.011, β = 0.088, p = 0.02) but not for CE (R 2 = 0.011, β = 0.013, p = 0.732). No significant association was found between ADHD PRS and RTV or CE in any sample individually (p > 0.10). We detected a significant association between PRS for ADHD and RTV (but not CE) in individuals with ADHD, suggesting that common genetic risk variants for ADHD influence attention regulation
Idioma originalInglés
Páginas (desde-hasta)3150-3158
Número de páginas9
PublicaciónPsychological Medicine
Volumen52
DOI
EstadoPublicada - 2022

Huella

Profundice en los temas de investigación de 'Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments'. En conjunto forman una huella única.

Citar esto