Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

L. Calpe-Berdiel; J. C. Escolà-Gil; Noemi Rotllan; F. Blanco-Vaca

doi:10.1016/j.metabol.2008.06.002

Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

L. Calpe-Berdiel, J. C. Escolà-Gil, Noemi Rotllan, F. Blanco-Vaca

Departamento de Bioquímica y Biología Molecular

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

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Resumen

Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. © 2008 Elsevier Inc. All rights reserved.

Idioma original	Inglés
Páginas (desde-hasta)	1497-1501
Publicación	Metabolism: Clinical and Experimental
Volumen	57
N.º	11
DOI	https://doi.org/10.1016/j.metabol.2008.06.002
Estado	Publicada - 1 nov 2008

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title = "Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice",

abstract = "Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

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Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice. / Calpe-Berdiel, L.; Escolà-Gil, J. C.; Rotllan, Noemi et al.
En: Metabolism: Clinical and Experimental, Vol. 57, N.º 11, 01.11.2008, p. 1497-1501.

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

TY - JOUR

T1 - Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

AU - Calpe-Berdiel, L.

AU - Escolà-Gil, J. C.

AU - Rotllan, Noemi

AU - Blanco-Vaca, F.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. © 2008 Elsevier Inc. All rights reserved.

AB - Most studies have focused on the cholesterol-lowering activity of phytosterols; however, other biological actions have also been attributed to these plant compounds. In this study, we investigated whether phytosterols could delay (progression phase) and/or reverse (regression phase) insulin resistance or type 2 diabetes mellitus in an experimental mouse model of diet-induced obesity, insulin resistance, and diabetes. Body mass, plasma lipid levels, insulin resistance, and hyperglycemia were determined. Phytosterol intake did not improve these metabolic parameters. Therefore, we were unable to substantiate any protective effect of phytosterol intake on diabetes development or regression in the mouse model used. © 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.metabol.2008.06.002

DO - 10.1016/j.metabol.2008.06.002

M3 - Article

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VL - 57

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JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 11

ER -

Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

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