Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults

T. Laue; M.P. Ballester; L. Meoli; C. Grabitz; E. Uson; L. Dantiga; V. Mclin; M. Pujadas; Â. Carvalho-Gomes; I. Sahuco; A. Bono; F. D'amico; R. Viganò; E. Diago; B.T. Lanseros; E. Inglese; Dani Martinez Vazquez; A. Broekhoven; M. Kikkert; S.P.T. Morales; S.K. Myeni; Mar Riveiro Barciela; Adriana Palom; N. Zeni; A. Brocca; A. Cussigh; S. Cmet; M.D. Escudero-García; M. Stocco; L.A. Natola; D. Ieluzzi; V. Paon; A. Sangiovanni; E. Farina; C. Dibenedetto; Y. Sánchez-Torrijos; A. Lucena-Varela; Eva Roman; Elisabet Sánchez; R. Sánchez-Aldehuelo; J. López-Cardona; D. Jeyanesan; A.E. Morocho; I. Canas-Perez; C. Eastgate; S. Di Cola; L. Lapenna; Giacomo Zaccherini; D. Bongiovanni; A. Riva; R. Sharma; H.L.P. Tsou; N. Harris; P. Zanaga; K. Sayaf; S. Hossain; J. Crespo; M. Robles-Díaz; A. Madejón; H. Degroote; M. Korenjak; X. Verhelst; J. García-Samaniego; R.J. Andrade; P. Iruzubieta; G. Wright; Paolo Caraceni; Manuela Merli; V.C. Patel; A. Gander; Agustín Albillos; German Soriano; M.F. Donato; D. Sacerdoti; P. Toniutto; Maria Buti; C. Duvoux; P.A. Grossi; T. Berg; W.G. Polak; M. Puoti; A. Bosch-Comas; L.S. Belli; P. Burra; F.P. Russo; M. Coenraad; Jose Luis Calleja; G. Perricone; S. Chokshi; M. Berenguer; Joan Claria; Richard Moreau; J. Fernández; Vicente Arroyo; Paolo Angeli; C. Sánchez-Garrido; Javier Ampuero; S. Piano; E. Nicastro; N. Rock; D. Shawcross; L. Edwards; F. Mutschler; A. Melk; G. Mehta; U. Baumann; R. Jalan

doi:10.1097/TXD.0000000000001787

Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults

T. Laue, M.P. Ballester, L. Meoli, C. Grabitz, E. Uson, L. Dantiga, V. Mclin, M. Pujadas, Â. Carvalho-Gomes, I. Sahuco, A. Bono, F. D'amico, R. Viganò, E. Diago, B.T. Lanseros, E. Inglese, Dani Martinez Vazquez, A. Broekhoven, M. Kikkert, S.P.T. MoralesS.K. Myeni, Mar Riveiro Barciela, Adriana Palom, N. Zeni, A. Brocca, A. Cussigh, S. Cmet, M.D. Escudero-García, M. Stocco, L.A. Natola, D. Ieluzzi, V. Paon, A. Sangiovanni, E. Farina, C. Dibenedetto, Y. Sánchez-Torrijos, A. Lucena-Varela, Eva Roman, Elisabet Sánchez, R. Sánchez-Aldehuelo, J. López-Cardona, D. Jeyanesan, A.E. Morocho, I. Canas-Perez, C. Eastgate, S. Di Cola, L. Lapenna, Giacomo Zaccherini, D. Bongiovanni, A. Riva, R. Sharma, H.L.P. Tsou, N. Harris, P. Zanaga, K. Sayaf, S. Hossain, J. Crespo, M. Robles-Díaz, A. Madejón, H. Degroote, M. Korenjak, X. Verhelst, J. García-Samaniego, R.J. Andrade, P. Iruzubieta, G. Wright, Paolo Caraceni, Manuela Merli, V.C. Patel, A. Gander, Agustín Albillos, German Soriano, M.F. Donato, D. Sacerdoti, P. Toniutto, Maria Buti, C. Duvoux, P.A. Grossi, T. Berg, W.G. Polak, M. Puoti, A. Bosch-Comas, L.S. Belli, P. Burra, F.P. Russo, M. Coenraad, Jose Luis Calleja, G. Perricone, S. Chokshi, M. Berenguer, Joan Claria, Richard Moreau, J. Fernández, Vicente Arroyo, Paolo Angeli, C. Sánchez-Garrido, Javier Ampuero, S. Piano, E. Nicastro, N. Rock, D. Shawcross, L. Edwards, F. Mutschler, A. Melk, G. Mehta, U. Baumann, R. Jalan

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Resumen

Background. Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR. Methods. A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA. Results. A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR. Conclusions. Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.

Idioma original	Inglés
Publicación	Transplantation Direct
Volumen	11
N.º	5
DOI	https://doi.org/10.1097/TXD.0000000000001787
Estado	Publicada - 2025

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Laue, T., Ballester, M. P., Meoli, L., Grabitz, C., Uson, E., Dantiga, L., Mclin, V., Pujadas, M., Carvalho-Gomes, Â., Sahuco, I., Bono, A., D'amico, F., Viganò, R., Diago, E., Lanseros, B. T., Inglese, E., Vazquez, D. M., Broekhoven, A., Kikkert, M., ... Jalan, R. (2025). Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults. Transplantation Direct, 11(5). https://doi.org/10.1097/TXD.0000000000001787

@article{f19dee9ac2724b55867d1906c8b70e2d,

title = "Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults",

abstract = "Background. Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR. Methods. A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA. Results. A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94\% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR. Conclusions. Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.",

author = "T. Laue and M.P. Ballester and L. Meoli and C. Grabitz and E. Uson and L. Dantiga and V. Mclin and M. Pujadas and {\^A}. Carvalho-Gomes and I. Sahuco and A. Bono and F. D'amico and R. Vigan{\`o} and E. Diago and B.T. Lanseros and E. Inglese and Vazquez, \{Dani Martinez\} and A. Broekhoven and M. Kikkert and S.P.T. Morales and S.K. Myeni and \{Riveiro Barciela\}, Mar and Adriana Palom and N. Zeni and A. Brocca and A. Cussigh and S. Cmet and M.D. Escudero-Garc{\'i}a and M. Stocco and L.A. Natola and D. Ieluzzi and V. Paon and A. Sangiovanni and E. Farina and C. Dibenedetto and Y. S{\'a}nchez-Torrijos and A. Lucena-Varela and Eva Roman and Elisabet S{\'a}nchez and R. S{\'a}nchez-Aldehuelo and J. L{\'o}pez-Cardona and D. Jeyanesan and A.E. Morocho and I. Canas-Perez and C. Eastgate and \{Di Cola\}, S. and L. Lapenna and Giacomo Zaccherini and D. Bongiovanni and A. Riva and R. Sharma and H.L.P. Tsou and N. Harris and P. Zanaga and K. Sayaf and S. Hossain and J. Crespo and M. Robles-D{\'i}az and A. Madej{\'o}n and H. Degroote and M. Korenjak and X. Verhelst and J. Garc{\'i}a-Samaniego and R.J. Andrade and P. Iruzubieta and G. Wright and Paolo Caraceni and Manuela Merli and V.C. Patel and A. Gander and Agust{\'i}n Albillos and German Soriano and M.F. Donato and D. Sacerdoti and P. Toniutto and Maria Buti and C. Duvoux and P.A. Grossi and T. Berg and W.G. Polak and M. Puoti and A. Bosch-Comas and L.S. Belli and P. Burra and F.P. Russo and M. Coenraad and Calleja, \{Jose Luis\} and G. Perricone and S. Chokshi and M. Berenguer and Joan Claria and Richard Moreau and J. Fern{\'a}ndez and Vicente Arroyo and Paolo Angeli and C. S{\'a}nchez-Garrido and Javier Ampuero and S. Piano and E. Nicastro and N. Rock and D. Shawcross and L. Edwards and F. Mutschler and A. Melk and G. Mehta and U. Baumann and R. Jalan",

year = "2025",

doi = "10.1097/TXD.0000000000001787",

language = "English",

volume = "11",

journal = "Transplantation Direct",

issn = "2373-8731",

publisher = "Wolters Kluwer Health",

number = "5",

}

Laue, T, Ballester, MP, Meoli, L, Grabitz, C, Uson, E, Dantiga, L, Mclin, V, Pujadas, M, Carvalho-Gomes, Â, Sahuco, I, Bono, A, D'amico, F, Viganò, R, Diago, E, Lanseros, BT, Inglese, E, Vazquez, DM, Broekhoven, A, Kikkert, M, Morales, SPT, Myeni, SK, Riveiro Barciela, M, Palom, A, Zeni, N, Brocca, A, Cussigh, A, Cmet, S, Escudero-García, MD, Stocco, M, Natola, LA, Ieluzzi, D, Paon, V, Sangiovanni, A, Farina, E, Dibenedetto, C, Sánchez-Torrijos, Y, Lucena-Varela, A, Roman, E, Sánchez, E, Sánchez-Aldehuelo, R, López-Cardona, J, Jeyanesan, D, Morocho, AE, Canas-Perez, I, Eastgate, C, Di Cola, S, Lapenna, L, Zaccherini, G, Bongiovanni, D, Riva, A, Sharma, R, Tsou, HLP, Harris, N, Zanaga, P, Sayaf, K, Hossain, S, Crespo, J, Robles-Díaz, M, Madejón, A, Degroote, H, Korenjak, M, Verhelst, X, García-Samaniego, J, Andrade, RJ, Iruzubieta, P, Wright, G, Caraceni, P, Merli, M, Patel, VC, Gander, A, Albillos, A, Soriano, G, Donato, MF, Sacerdoti, D, Toniutto, P, Buti, M, Duvoux, C, Grossi, PA, Berg, T, Polak, WG, Puoti, M, Bosch-Comas, A, Belli, LS, Burra, P, Russo, FP, Coenraad, M, Calleja, JL, Perricone, G, Chokshi, S, Berenguer, M, Claria, J, Moreau, R, Fernández, J, Arroyo, V, Angeli, P, Sánchez-Garrido, C, Ampuero, J, Piano, S, Nicastro, E, Rock, N, Shawcross, D, Edwards, L, Mutschler, F, Melk, A, Mehta, G, Baumann, U & Jalan, R 2025, 'Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults', Transplantation Direct, vol. 11, n.º 5. https://doi.org/10.1097/TXD.0000000000001787

TY - JOUR

T1 - Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults

AU - Laue, T.

AU - Ballester, M.P.

AU - Meoli, L.

AU - Grabitz, C.

AU - Uson, E.

AU - Dantiga, L.

AU - Mclin, V.

AU - Pujadas, M.

AU - Carvalho-Gomes, Â.

AU - Sahuco, I.

AU - Bono, A.

AU - D'amico, F.

AU - Viganò, R.

AU - Diago, E.

AU - Lanseros, B.T.

AU - Inglese, E.

AU - Vazquez, Dani Martinez

AU - Broekhoven, A.

AU - Kikkert, M.

AU - Morales, S.P.T.

AU - Myeni, S.K.

AU - Riveiro Barciela, Mar

AU - Palom, Adriana

AU - Zeni, N.

AU - Brocca, A.

AU - Cussigh, A.

AU - Cmet, S.

AU - Escudero-García, M.D.

AU - Stocco, M.

AU - Natola, L.A.

AU - Ieluzzi, D.

AU - Paon, V.

AU - Sangiovanni, A.

AU - Farina, E.

AU - Dibenedetto, C.

AU - Sánchez-Torrijos, Y.

AU - Lucena-Varela, A.

AU - Roman, Eva

AU - Sánchez, Elisabet

AU - Sánchez-Aldehuelo, R.

AU - López-Cardona, J.

AU - Jeyanesan, D.

AU - Morocho, A.E.

AU - Canas-Perez, I.

AU - Eastgate, C.

AU - Di Cola, S.

AU - Lapenna, L.

AU - Zaccherini, Giacomo

AU - Bongiovanni, D.

AU - Riva, A.

AU - Sharma, R.

AU - Tsou, H.L.P.

AU - Harris, N.

AU - Zanaga, P.

AU - Sayaf, K.

AU - Hossain, S.

AU - Crespo, J.

AU - Robles-Díaz, M.

AU - Madejón, A.

AU - Degroote, H.

AU - Korenjak, M.

AU - Verhelst, X.

AU - García-Samaniego, J.

AU - Andrade, R.J.

AU - Iruzubieta, P.

AU - Wright, G.

AU - Caraceni, Paolo

AU - Merli, Manuela

AU - Patel, V.C.

AU - Gander, A.

AU - Albillos, Agustín

AU - Soriano, German

AU - Donato, M.F.

AU - Sacerdoti, D.

AU - Toniutto, P.

AU - Buti, Maria

AU - Duvoux, C.

AU - Grossi, P.A.

AU - Berg, T.

AU - Polak, W.G.

AU - Puoti, M.

AU - Bosch-Comas, A.

AU - Belli, L.S.

AU - Burra, P.

AU - Russo, F.P.

AU - Coenraad, M.

AU - Calleja, Jose Luis

AU - Perricone, G.

AU - Chokshi, S.

AU - Berenguer, M.

AU - Claria, Joan

AU - Moreau, Richard

AU - Fernández, J.

AU - Arroyo, Vicente

AU - Angeli, Paolo

AU - Sánchez-Garrido, C.

AU - Ampuero, Javier

AU - Piano, S.

AU - Nicastro, E.

AU - Rock, N.

AU - Shawcross, D.

AU - Edwards, L.

AU - Mutschler, F.

AU - Melk, A.

AU - Mehta, G.

AU - Baumann, U.

AU - Jalan, R.

PY - 2025

Y1 - 2025

N2 - Background. Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR. Methods. A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA. Results. A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR. Conclusions. Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.

AB - Background. Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR. Methods. A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA. Results. A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR. Conclusions. Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.

U2 - 10.1097/TXD.0000000000001787

DO - 10.1097/TXD.0000000000001787

M3 - Article

C2 - 40309027

SN - 2373-8731

VL - 11

JO - Transplantation Direct

JF - Transplantation Direct

IS - 5

ER -

Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults

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