P21(WAF1/Cip1) expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx

A Nadal, P Jares, M Cazorla, PL Fernandez, G. Sanjuan, L Hernandez, M Pinyol, M Aldea, C Mallofre, J Muntane, J Traserra, E Campo, A Cardesa

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58 Citas (Scopus)

Resumen

p21(WAF1/Cip1) is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines stems to be induced by wild-type, but not mutant, p53, p21(WAF1/Cip1) expression has been studied at both mRNA and protein levels in a series of 49 normal mucosae and squamous cell carcinomas of the larynx, A significant association was found between mRNA and protein expression in tumours (P

Idioma originalInglés
Páginas (desde-hasta)156-163
Número de páginas8
PublicaciónJ. Pathol.
Volumen183
N.º2
EstadoPublicada - oct 1997

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