TY - JOUR
T1 - Outcome of HCV/HIV-coinfected liver transplant recipients
T2 - A prospective and multicenter cohort study
AU - Miro, J. M.
AU - Montejo, M.
AU - Castells, L.
AU - Rafecas, A.
AU - Moreno, S.
AU - Agüero, F.
AU - Abradelo, M.
AU - Miralles, P.
AU - Torre-Cisneros, J.
AU - Pedreira, J. D.
AU - Cordero, E.
AU - de la Rosa, G.
AU - Moyano, B.
AU - Moreno, A.
AU - Perez, I.
AU - Rimola, A.
AU - Castro, M. A.
AU - López, S.
AU - Suárez, F.
AU - Vázquez, P.
AU - Blanch, J.
AU - Brunet, M.
AU - Cervera, C.
AU - de Lazzari, E.
AU - Fondevila, C.
AU - Forner, A.
AU - Fuster, J.
AU - Freixa, N.
AU - García-Valdecasas, J. C.
AU - Gil, A.
AU - Gatell, J. M.
AU - Laguno, M.
AU - Larrousse, M.
AU - Mallolas, J.
AU - Manzardo, C.
AU - Monrás, M.
AU - Murillas, J.
AU - Paredes, D.
AU - Pérez, I.
AU - Torres, F.
AU - Tural, C.
AU - Tuset, M.
AU - Antela, A.
AU - Losada, E.
AU - Molina, E.
AU - Otero, E.
AU - Varo, E.
AU - Lozano, R.
AU - Campos-Varela, I.
AU - Vargas, V.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Eighty-four HCV/HIV-coinfected and 252-matched HCV-monoinfected liver transplant recipients were included in a prospective multicenter study. Thirtysix (43%) HCV/HIV-coinfected and 75 (30%) HCV-monoinfected patients died, with a survival rate at 5 years of 54% (95% CI, 42-64) and 71% (95% CI, 66 to 77; p = 0.008), respectively. When both groups were considered together, HIV infection was an independent predictor of mortality (HR, 2.202; 95% CI, 1.420-3.413 [p<0.001]). Multivariate analysis of only the HCV/HIV-coinfected recipients, revealed HCV genotype 1 (HR, 2.98; 95% CI, 1.32-6.76), donor risk index (HR, 9.48; 95% CI, 2.75-32.73) and negative plasma HCV RNA (HR, 0.14; 95% CI, 0.03-0.62) to be associated with mortality. When this analysis was restricted to pretransplant variables, we identified three independent factors (HCV genotype 1, pretransplant MELD score and centers with <1 liver transplantation/year in HIV-infected patients) that allowed us to identify a subset of 60 (71%) patients with a similar 5-year prognosis (69% [95% CI, 54-80]) to that of HCV-monoinfected recipients. In conclusion, 5-year survival in HCV/HIV-coinfected liver recipients was lower than in HCV-monoinfected recipients, although an important subset with a favorable prognosis was identified in the former.
AB - Eighty-four HCV/HIV-coinfected and 252-matched HCV-monoinfected liver transplant recipients were included in a prospective multicenter study. Thirtysix (43%) HCV/HIV-coinfected and 75 (30%) HCV-monoinfected patients died, with a survival rate at 5 years of 54% (95% CI, 42-64) and 71% (95% CI, 66 to 77; p = 0.008), respectively. When both groups were considered together, HIV infection was an independent predictor of mortality (HR, 2.202; 95% CI, 1.420-3.413 [p<0.001]). Multivariate analysis of only the HCV/HIV-coinfected recipients, revealed HCV genotype 1 (HR, 2.98; 95% CI, 1.32-6.76), donor risk index (HR, 9.48; 95% CI, 2.75-32.73) and negative plasma HCV RNA (HR, 0.14; 95% CI, 0.03-0.62) to be associated with mortality. When this analysis was restricted to pretransplant variables, we identified three independent factors (HCV genotype 1, pretransplant MELD score and centers with <1 liver transplantation/year in HIV-infected patients) that allowed us to identify a subset of 60 (71%) patients with a similar 5-year prognosis (69% [95% CI, 54-80]) to that of HCV-monoinfected recipients. In conclusion, 5-year survival in HCV/HIV-coinfected liver recipients was lower than in HCV-monoinfected recipients, although an important subset with a favorable prognosis was identified in the former.
KW - HCV infection
KW - HIV infection
KW - Liver transplantation
KW - Spain
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84863300076&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2012.04028.x
DO - 10.1111/j.1600-6143.2012.04028.x
M3 - Artículo
C2 - 22471341
AN - SCOPUS:84863300076
SN - 1600-6135
VL - 12
SP - 1866
EP - 1876
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 7
ER -