TY - JOUR
T1 - Novobiocin inhibits the antimicrobial resistance acquired through DNA damage-induced mutagenesis in Acinetobacter baumannii
AU - Jara, Luis M.
AU - Pérez-Varela, María
AU - Corral, Jordi
AU - Arch, Marta
AU - Cortés, Pilar
AU - Bou, Germán
AU - Aranda, Jesús
AU - Barbé, Jordi
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Copyright © 2015, American Society for Microbiology. All Rights Reserved. Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.
AB - Copyright © 2015, American Society for Microbiology. All Rights Reserved. Acinetobacter baumannii, a worldwide emerging nosocomial pathogen, acquires antimicrobial resistances in response to DNA-damaging agents, which increase the expression of multiple error-prone DNA polymerase components. Here we show that the aminocoumarin novobiocin, which inhibits the DNA damage response in Gram-positive bacteria, also inhibits the expression of error-prone DNA polymerases in this Gram-negative multidrug-resistant pathogen and, consequently, its potential acquisition of antimicrobial resistance through DNA damage-induced mutagenesis.
U2 - 10.1128/AAC.01810-15
DO - 10.1128/AAC.01810-15
M3 - Article
SN - 0066-4804
VL - 60
SP - 637
EP - 639
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -