MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

Daniel Massó Vallés; Marie-Eve Beaulieu; Toni Jauset González; Fabio Giuntini; Mariano F Zacarías-Fluck; Laia Foradada; Sandra Martínez-Martín; Erika Serrano; Génesis Martín-Fernández; Sílvia Casacuberta-Serra; Virginia Castillo Cano; Jastrinjan Kaur; Sergio López-Estévez; Miguel Ángel Morcillo; Mohammad Alzrigat; Loay Mahmoud; Antonio Luque-García; Marta Escorihuela; Marta Guzman; Joaquín V Arribas; Violeta Serra; Lars-Gunnar Larsson; Jonathan R. Whitfield; Laura Soucek

doi:10.1158/2767-9764.CRC-21-0103

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

Daniel Massó Vallés, Marie-Eve Beaulieu, Toni Jauset González, Fabio Giuntini, Mariano F Zacarías-Fluck, Laia Foradada, Sandra Martínez-Martín, Erika Serrano, Génesis Martín-Fernández, Sílvia Casacuberta-Serra, Virginia Castillo Cano, Jastrinjan Kaur, Sergio López-Estévez, Miguel Ángel Morcillo, Mohammad Alzrigat, Loay Mahmoud, Antonio Luque-García, Marta Escorihuela, Marta Guzman, Joaquín V ArribasVioleta Serra, Lars-Gunnar Larsson, Jonathan R. Whitfield, Laura Soucek

Departamento de Bioquímica y Biología Molecular

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

23 Citas (Scopus)

Resumen

While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.

Idioma original	Inglés
Páginas (desde-hasta)	110-130
Número de páginas	21
Publicación	Cancer Research Communications
Volumen	2
DOI	https://doi.org/10.1158/2767-9764.CRC-21-0103
Estado	Publicada - 2022

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10.1158/2767-9764.CRC-21-0103

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https://www.scopus.com/pages/publications/85147902001

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Massó Vallés, D., Beaulieu, M.-E., Jauset González, T., Giuntini, F., Zacarías-Fluck, M. F., Foradada, L., Martínez-Martín, S., Serrano, E., Martín-Fernández, G., Casacuberta-Serra, S., Castillo Cano, V., Kaur, J., López-Estévez, S., Morcillo, M. Á., Alzrigat, M., Mahmoud, L., Luque-García, A., Escorihuela, M., Guzman, M., ... Soucek, L. (2022). MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding. Cancer Research Communications, 2, 110-130. https://doi.org/10.1158/2767-9764.CRC-21-0103

@article{0c43dfa45374427995eee9c11d7f656f,

title = "MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding",

abstract = "While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.",

author = "\{Mass{\'o} Vall{\'e}s\}, Daniel and Marie-Eve Beaulieu and \{Jauset Gonz{\'a}lez\}, Toni and Fabio Giuntini and Zacar{\'i}as-Fluck, \{Mariano F\} and Laia Foradada and Sandra Mart{\'i}nez-Mart{\'i}n and Erika Serrano and G{\'e}nesis Mart{\'i}n-Fern{\'a}ndez and S{\'i}lvia Casacuberta-Serra and \{Castillo Cano\}, Virginia and Jastrinjan Kaur and Sergio L{\'o}pez-Est{\'e}vez and Morcillo, \{Miguel {\'A}ngel\} and Mohammad Alzrigat and Loay Mahmoud and Antonio Luque-Garc{\'i}a and Marta Escorihuela and Marta Guzman and Arribas, \{Joaqu{\'i}n V\} and Violeta Serra and Lars-Gunnar Larsson and Whitfield, \{Jonathan R.\} and Laura Soucek",

year = "2022",

doi = "10.1158/2767-9764.CRC-21-0103",

language = "English",

volume = "2",

pages = "110--130",

}

Massó Vallés, D, Beaulieu, M-E, Jauset González, T, Giuntini, F, Zacarías-Fluck, MF, Foradada, L, Martínez-Martín, S, Serrano, E, Martín-Fernández, G, Casacuberta-Serra, S, Castillo Cano, V, Kaur, J, López-Estévez, S, Morcillo, MÁ, Alzrigat, M, Mahmoud, L, Luque-García, A, Escorihuela, M, Guzman, M, Arribas, JV, Serra, V, Larsson, L-G, Whitfield, JR & Soucek, L 2022, 'MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding', Cancer Research Communications, vol. 2, pp. 110-130. https://doi.org/10.1158/2767-9764.CRC-21-0103

TY - JOUR

T1 - MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

AU - Massó Vallés, Daniel

AU - Beaulieu, Marie-Eve

AU - Jauset González, Toni

AU - Giuntini, Fabio

AU - Zacarías-Fluck, Mariano F

AU - Foradada, Laia

AU - Martínez-Martín, Sandra

AU - Serrano, Erika

AU - Martín-Fernández, Génesis

AU - Casacuberta-Serra, Sílvia

AU - Castillo Cano, Virginia

AU - Kaur, Jastrinjan

AU - López-Estévez, Sergio

AU - Morcillo, Miguel Ángel

AU - Alzrigat, Mohammad

AU - Mahmoud, Loay

AU - Luque-García, Antonio

AU - Escorihuela, Marta

AU - Guzman, Marta

AU - Arribas, Joaquín V

AU - Serra, Violeta

AU - Larsson, Lars-Gunnar

AU - Whitfield, Jonathan R.

AU - Soucek, Laura

PY - 2022

Y1 - 2022

N2 - While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.

AB - While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.

UR - https://www.scopus.com/pages/publications/85147902001

U2 - 10.1158/2767-9764.CRC-21-0103

DO - 10.1158/2767-9764.CRC-21-0103

M3 - Article

C2 - 36860495

SN - 2767-9764

VL - 2

SP - 110

EP - 130

JO - Cancer Research Communications

JF - Cancer Research Communications

ER -

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

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