Molecular analysis of ancient caries

Marc Simón; Rafael Montiel; Andrea Smerling; Eduvigis Solórzano; Nancy Díaz; Brenda A. Álvarez-Sandoval; Andrea R. Jiménez-Marín; Assumpció Malgosa

doi:10.1098/rspb.2014.0586

Molecular analysis of ancient caries

Marc Simón, Rafael Montiel, Andrea Smerling, Eduvigis Solórzano, Nancy Díaz, Brenda A. Álvarez-Sandoval, Andrea R. Jiménez-Marín, Assumpció Malgosa

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Resumen

An 84 base pair sequence of the Streptococcus mutansvirulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Idioma original	Inglés
Número de artículo	20140586
Publicación	Proceedings of the Royal Society B: Biological Sciences
Volumen	281
DOI	https://doi.org/10.1098/rspb.2014.0586
Estado	Publicada - 23 jul 2014

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title = "Molecular analysis of ancient caries",

abstract = "An 84 base pair sequence of the Streptococcus mutansvirulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains. {\textcopyright} 2014 The Author(s) Published by the Royal Society. All rights reserved.",

keywords = "Dextranase, Neutral evolution, Positive selection, Streptococcus mutans",

author = "Marc Sim{\'o}n and Rafael Montiel and Andrea Smerling and Eduvigis Sol{\'o}rzano and Nancy D{\'i}az and {\'A}lvarez-Sandoval, {Brenda A.} and Jim{\'e}nez-Mar{\'i}n, {Andrea R.} and Assumpci{\'o} Malgosa",

year = "2014",

month = jul,

day = "23",

doi = "10.1098/rspb.2014.0586",

language = "English",

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journal = "Proceedings of the Royal Society B: Biological Sciences",

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TY - JOUR

T1 - Molecular analysis of ancient caries

AU - Simón, Marc

AU - Montiel, Rafael

AU - Smerling, Andrea

AU - Solórzano, Eduvigis

AU - Díaz, Nancy

AU - Álvarez-Sandoval, Brenda A.

AU - Jiménez-Marín, Andrea R.

AU - Malgosa, Assumpció

PY - 2014/7/23

Y1 - 2014/7/23

N2 - An 84 base pair sequence of the Streptococcus mutansvirulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

AB - An 84 base pair sequence of the Streptococcus mutansvirulence factor, known as dextranase, has been obtained from 10 individuals from the Bronze Age to the Modern Era in Europe and from before and after the colonization in America. Modern samples show four polymorphic sites that have not been found in the ancient samples studied so far. The nucleotide and haplotype diversity of this region have increased over time, which could be reflecting the footprint of a population expansion. While this segment has apparently evolved according to neutral evolution, we have been able to detect one site that is under positive selection pressure both in present and past populations. This study is a first step to study the evolution of this microorganism, analysed using direct evidence obtained from ancient remains. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

KW - Dextranase

KW - Neutral evolution

KW - Positive selection

KW - Streptococcus mutans

U2 - 10.1098/rspb.2014.0586

DO - 10.1098/rspb.2014.0586

M3 - Article

SN - 0962-8452

VL - 281

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

M1 - 20140586

ER -

Molecular analysis of ancient caries

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