TY - JOUR
T1 - Moderate consumption of wine, through both its phenolic compounds and alcohol content, promotes hydroxytyrosol endogenous generation in humans. A randomized controlled trial
AU - Pérez-Mañá, Clara
AU - Farré, Magí
AU - Rodríguez-Morató, Jose
AU - Papaseit, Esther
AU - Pujadas, Mitona
AU - Fitó, Montserrat
AU - Robledo, Patricia
AU - Covas, Maria Isabel
AU - Cheynier, Véronique
AU - Meudec, Emmanuelle
AU - Escudier, Jean Louis
AU - de la Torre, Rafael
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. In humans, urinary hydroxytyrosol (OHTyr) concentrations have been associated to alcohol and wine consumption. To explore the role of wine components on promoting an endogenous OHTyr generation we performed a cross-over, double-blind, randomized controlled clinical trial (n = 28 healthy volunteers). Ethanol (wine and vodka), dealcoholized wine, and placebo were administered. Alcohol, dealcoholized wine, and particularly wine promoted a de novo OHTyr generation in vivo in humans. Potential OHTyr precursors (tyrosine, tyrosol, tyramine) were investigated in rats. Tyrosol was metabolized to OHTyr. Collating both studies, it is postulated that an increased Tyr bioavailability, a shift to a reductive pathway in dopamine and tyramine oxidative metabolism, and the biotransformation of Tyr to OHTyr were mechanisms involved in the OHTyr endogenous generation.
AB - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. In humans, urinary hydroxytyrosol (OHTyr) concentrations have been associated to alcohol and wine consumption. To explore the role of wine components on promoting an endogenous OHTyr generation we performed a cross-over, double-blind, randomized controlled clinical trial (n = 28 healthy volunteers). Ethanol (wine and vodka), dealcoholized wine, and placebo were administered. Alcohol, dealcoholized wine, and particularly wine promoted a de novo OHTyr generation in vivo in humans. Potential OHTyr precursors (tyrosine, tyrosol, tyramine) were investigated in rats. Tyrosol was metabolized to OHTyr. Collating both studies, it is postulated that an increased Tyr bioavailability, a shift to a reductive pathway in dopamine and tyramine oxidative metabolism, and the biotransformation of Tyr to OHTyr were mechanisms involved in the OHTyr endogenous generation.
KW - Alcohol
KW - Dopamine metabolism
KW - Hydroxytyrosol
KW - Tyrosol
KW - Wine
U2 - 10.1002/mnfr.201400842
DO - 10.1002/mnfr.201400842
M3 - Article
SN - 1613-4125
VL - 59
SP - 1213
EP - 1216
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 6
ER -