Methylclock: A Bioconductor package to estimate DNA methylation age methylclock: A Bioconductor package to estimate DNA methylation age

Dolors Pelegi-Siso, Paula De Prado, Justiina Ronkainen, Mariona Bustamante, Juan R. Gonzalez*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

72 Citas (Scopus)

Resumen

Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks.

Idioma originalInglés
Páginas (desde-hasta)1759-1760
Número de páginas2
PublicaciónBioinformatics
Volumen37
N.º12
DOI
EstadoPublicada - 15 jun 2021

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Profundice en los temas de investigación de 'Methylclock: A Bioconductor package to estimate DNA methylation age methylclock: A Bioconductor package to estimate DNA methylation age'. En conjunto forman una huella única.

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