Measurement of asthma control according to global initiative for asthma guidelines: a comparison with the asthma control questionnaire

José M. Olaguibel, Santiago Quirce, Berta Juliá*, Cristina Fernández, Ana M. Fortuna, Jesús Molina, Vicente Plaza, María Aguar, Ramón Agüero, Dolores Aicart, Teresa Almela, Carlos Almonacid, Alicia Alonso, Francisco Álvarez, Julio Álvarez, María Álvarez, Pedro Álvarez, Javier Amiama, Ignacio Antepara, Margarita ArmisenAurelio Arnedillo, Mikel Azpiazu, Javier Barrio, Teresa Bazús, Dolores Bello, Miguel Bentabol, Ana Beristain, Carlos Blanco, Rosa Blanco, Luís Borderías, Ana Bustamante, Pedro Caballero, Pedro Cabrera, Francisco Calero, Eduardo Calvo, Gabriela Cantó, Concepción Cañete, Francisco Carballada, Remedios Cárdenas, Manuel Carpintero, Pedro Carretero, Teresa Carrillo, María Casado, Francisco Casas, Pilar Cebollero, Carolina Cisneros, Lourdes Clemente, Carlos Colas, José Compaired, Jose García

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

88 Citas (Scopus)

Resumen

Introduction: Asthma Control Questionnaire (ACQ) is a validated tool to measure asthma control. Cut-off points that best discriminate " well-controlled" or " not well-controlled" asthma have been suggested from the analysis of a large randomized clinical trial but they may not be adequate for daily clinical practice.Aims: To establish cut-off points of the ACQ that best discriminate the level of control according to Global Initiative for Asthma (GINA) 2006 guidelines in patients with asthma managed at Allergology and Pulmonology Departments as well as Primary Care Centers in Spain.Patients and methods: An epidemiological descriptive study, with prospective data collection. Asthma control following GINA-2006 classification and 7-item ACQ was assessed. The study population was split in two parts: 2/3 for finding the cut-off points (development population) and 1/3 for validating the results (validation population).Results: A total of 1,363 stable asthmatic patients were included (mean age 38 ± 14 years, 60.3% women; 69.1% non-smokers). Patient classification according to GINA-defined asthma control was: controlled 13.6%, partially controlled 34.2%, and uncontrolled 52.3%. The ACQ cut-off points that better agreed with GINA-defined asthma control categories were calculated using receiver operating curves (ROC). The analysis showed that ACQ < 0.5 was the optimal cut-off point for " controlled asthma" (sensitivity 74.1%, specificity 77.5%) and 1.00 for " uncontrolled asthma" (sensitivity 73%, specificity 88.2%). Kappa index between GINA categories and ACQ was 0.62 (p < 0.001).Conclusion: The ACQ cut-off points associated with GINA-defined asthma control in a real-life setting were <0.5 for controlled asthma and ≥1 for uncontrolled asthma.

Idioma originalInglés
Número de artículo50
PublicaciónRespiratory Research
Volumen13
DOI
EstadoPublicada - 22 jun 2012

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