TY - JOUR
T1 - Maternal dietary phylloquinone intake (vitamin K1) and early childhood neurodevelopment
AU - Mateu-Fabregat, Javier
AU - Panisello, Laura
AU - Novau-Ferré, Nil
AU - Pinar-Martí, Ariadna
AU - Jimenez-Arenas, Pol
AU - Ferrer, Muriel
AU - Rivas, Ioar
AU - Llurba, Elisa
AU - Lassale, Camille
AU - Gómez-Roig, María Dolores
AU - Vioque, Jesús
AU - González-Palacios, Sandra
AU - Contreras-Rodríguez, Oren
AU - Arija, Victoria
AU - Foraster, Maria
AU - Gascon, Mireia
AU - Dadvand, Payam
AU - Sunyer, Jordi
AU - Júlvez, Jordi
AU - Bulló, Mònica
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2025.
PY - 2025/10/21
Y1 - 2025/10/21
N2 - Background: Maternal nutrition is a crucial modifiable factor with phylloquinone being involved in processes related to optimal brain development. This study aimed to evaluate the associations between maternal phylloquinone intake during pregnancy and early neurodevelopment in children. Methods: This study included 1080 pregnant women and their offspring from the Barcelona Life Study Cohort (BiSC). Maternal phylloquinone intake during pregnancy was estimated using a validated semiquantitative 114-item food frequency questionnaire. The Developmental Profile 3 (DP-3) and the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) were administered during early childhood. Statistical analysis was conducted using multivariable linear mixed-effects models and linear regression models. Results: Higher maternal dietary phylloquinone intake during pregnancy was associated with increased global developmental index scores (β [95% CI]: 0.88 [0.10, 1.66]) and better cognitive (β [95% CI]: 0.87 [0.14, 1.60]) and physical development (β [95% CI]: 0.72 [0.02, 1.42]), based on DP-3 scores. Similarly, motor development assessed through BSID-III scores was consistently higher in offspring of mothers within the highest phylloquinone intake (β [95% CI]: 1.69 [0.008, 3.38]). Conclusion: Higher dietary phylloquinone intake during pregnancy was associated with improved offspring neurodevelopment, emphasizing the need for tailored recommendations during pregnancy to support optimal brain development. Impact: Prenatal maternal nutrition has been recognized as a critical modifiable factor influencing optimal brain development. No previous studies have examined the impact of maternal phylloquinone intake during pregnancy on neurodevelopment. Higher maternal dietary intake of phylloquinone was associated with higher global developmental index scores, as well as improved cognitive and physical development in early childhood. These findings emphasize the need for tailored vitamin K recommendations during pregnancy to support optimal brain development in offspring.
AB - Background: Maternal nutrition is a crucial modifiable factor with phylloquinone being involved in processes related to optimal brain development. This study aimed to evaluate the associations between maternal phylloquinone intake during pregnancy and early neurodevelopment in children. Methods: This study included 1080 pregnant women and their offspring from the Barcelona Life Study Cohort (BiSC). Maternal phylloquinone intake during pregnancy was estimated using a validated semiquantitative 114-item food frequency questionnaire. The Developmental Profile 3 (DP-3) and the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) were administered during early childhood. Statistical analysis was conducted using multivariable linear mixed-effects models and linear regression models. Results: Higher maternal dietary phylloquinone intake during pregnancy was associated with increased global developmental index scores (β [95% CI]: 0.88 [0.10, 1.66]) and better cognitive (β [95% CI]: 0.87 [0.14, 1.60]) and physical development (β [95% CI]: 0.72 [0.02, 1.42]), based on DP-3 scores. Similarly, motor development assessed through BSID-III scores was consistently higher in offspring of mothers within the highest phylloquinone intake (β [95% CI]: 1.69 [0.008, 3.38]). Conclusion: Higher dietary phylloquinone intake during pregnancy was associated with improved offspring neurodevelopment, emphasizing the need for tailored recommendations during pregnancy to support optimal brain development. Impact: Prenatal maternal nutrition has been recognized as a critical modifiable factor influencing optimal brain development. No previous studies have examined the impact of maternal phylloquinone intake during pregnancy on neurodevelopment. Higher maternal dietary intake of phylloquinone was associated with higher global developmental index scores, as well as improved cognitive and physical development in early childhood. These findings emphasize the need for tailored vitamin K recommendations during pregnancy to support optimal brain development in offspring.
KW - Association
KW - Bone
KW - Cytokines
KW - Exposure
KW - Men
KW - Serum osteocalcin
UR - https://www.scopus.com/pages/publications/105019371394
U2 - 10.1038/s41390-025-04543-7
DO - 10.1038/s41390-025-04543-7
M3 - Article
C2 - 41120727
AN - SCOPUS:105019371394
SN - 0031-3998
JO - Pediatric Research
JF - Pediatric Research
ER -