Resumen
Background: Lysophosphatidic acid (LPA) is a bioactive lipid with pleiotropic activities due to activation of six receptors (LPA1-6). Results: Genetic deletion and pharmacological blockade of LPA1 inhibit differentiation and bone degradation activity of osteoclasts. Conclusion: LPA controls bone homeostasis through the activation of LPA1 expressed by osteoclasts. Significance: LPA1 is a new therapeutic target of diseases with excess bone degradation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Idioma original | Inglés |
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Páginas (desde-hasta) | 6551-6564 |
Publicación | Journal of Biological Chemistry |
Volumen | 289 |
N.º | 10 |
DOI | |
Estado | Publicada - 7 mar 2014 |