TY - JOUR
T1 - Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia :
T2 - Impact of Angiogenic Imbalance During Pregnancy
AU - Costa, Noah
AU - Platero, Judit
AU - García Manau, Pablo
AU - Sánchez García, Olga
AU - Jordi, Mariona
AU - García Ruiz, Zoraida
AU - Garrido-Giménez, Carmen
AU - Ullmo, Johana
AU - Nan, Madalina Nicoleta
AU - Mora Brugués, Josefina
AU - García Osuna, Álvaro
AU - Choliz, Marta
AU - Cruz-Lemini, Monica
AU - Llurba, Elisa
AU - Pellicer, Claudia
AU - Medina Mallen, Maria del Carmen
PY - 2025
Y1 - 2025
N2 - Background/Objectives: Preeclampsia is associated with long-term cardiovascular and metabolic risks. This study aimed to evaluate metabolic and cardiovascular biochemical profiles in women with a history of preeclampsia and angiogenic imbalance during pregnancy. Methods: We conducted a cross-sectional study at Hospital de la Santa Creu i Sant Pau between August 2023 and July 2025. Participants had been prospectively enrolled during pregnancy (2018-2022) and were re-evaluated 3 to 6 years later. Blood and urine samples were collected after a 12-h fast to assess hematological, metabolic, and cardiovascular markers. Angiogenic profiles were determined using sFlt-1/PlGF ratios obtained during pregnancy. Multivariable linear regression models were used to assess associations with a history of PE and angiogenic imbalance, adjusting for relevant confounders. Results: 363 participants were included. 113 (31.1%) had a history of preeclampsia. Women with previous preeclampsia showed slightly higher high-sensitivity troponin T concentrations [4.0 (3.0-6.0) ng/L vs. 3.2 (3.0-5.0) ng/L, p = 0.03]. Women with sFlt-1/PlGF ≥38 exhibited significantly higher urinary protein [0.09 (0.07-0.18) g/L vs. 0.08 (0.07-0.13) g/L, p = 0.01], potassium [4.25 (4.07-4.40) mmol/L vs. 4.19 (4.02-4.37) mmol/L, p = 0.048], and LDH concentrations [168 (150-189) U/L vs. 163 (149-177) U/L, p = 0.046], and lower leukocyte counts [6150 (5348-7055) vs. 6250 (5430-7450) U/mL, p = 0.03]. Conclusions: Women with angiogenic imbalance during pregnancy display subtle alterations in renal and endothelial function markers years after delivery, whereas those with preeclampsia show slightly higher troponin concentrations. These findings, though clinically irrelevant, suggest that pregnancy-related vascular dysfunction may have different long-term manifestations depending on whether the maternal cardiovascular system was sufficiently compromised to develop overt preeclampsia.
AB - Background/Objectives: Preeclampsia is associated with long-term cardiovascular and metabolic risks. This study aimed to evaluate metabolic and cardiovascular biochemical profiles in women with a history of preeclampsia and angiogenic imbalance during pregnancy. Methods: We conducted a cross-sectional study at Hospital de la Santa Creu i Sant Pau between August 2023 and July 2025. Participants had been prospectively enrolled during pregnancy (2018-2022) and were re-evaluated 3 to 6 years later. Blood and urine samples were collected after a 12-h fast to assess hematological, metabolic, and cardiovascular markers. Angiogenic profiles were determined using sFlt-1/PlGF ratios obtained during pregnancy. Multivariable linear regression models were used to assess associations with a history of PE and angiogenic imbalance, adjusting for relevant confounders. Results: 363 participants were included. 113 (31.1%) had a history of preeclampsia. Women with previous preeclampsia showed slightly higher high-sensitivity troponin T concentrations [4.0 (3.0-6.0) ng/L vs. 3.2 (3.0-5.0) ng/L, p = 0.03]. Women with sFlt-1/PlGF ≥38 exhibited significantly higher urinary protein [0.09 (0.07-0.18) g/L vs. 0.08 (0.07-0.13) g/L, p = 0.01], potassium [4.25 (4.07-4.40) mmol/L vs. 4.19 (4.02-4.37) mmol/L, p = 0.048], and LDH concentrations [168 (150-189) U/L vs. 163 (149-177) U/L, p = 0.046], and lower leukocyte counts [6150 (5348-7055) vs. 6250 (5430-7450) U/mL, p = 0.03]. Conclusions: Women with angiogenic imbalance during pregnancy display subtle alterations in renal and endothelial function markers years after delivery, whereas those with preeclampsia show slightly higher troponin concentrations. These findings, though clinically irrelevant, suggest that pregnancy-related vascular dysfunction may have different long-term manifestations depending on whether the maternal cardiovascular system was sufficiently compromised to develop overt preeclampsia.
KW - Preeclampsia
KW - sFlt-1
KW - PlGF
KW - Cardiovascular risk
KW - Endothelial dysfunction
KW - Metabolic profile
KW - Biomarkers
U2 - 10.3390/jcm14238389
DO - 10.3390/jcm14238389
M3 - Article
C2 - 41375695
SN - 2077-0383
VL - 14
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -