Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults

Luis Marcos-Vidal, Magdalena Martínez-García, Daniel Martín de Blas, Francisco J. Navas-Sánchez, Clara Pretus, Josep Antoni Ramos-Quiroga, Vanesa Richarte, Óscar Vilarroya, Jorge Sepulcre, Manuel Desco*, Susanna Carmona

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

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Resumen

Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion: Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.

Idioma originalInglés
Número de artículo10870547221101646
Páginas (desde-hasta)1788-1801
Número de páginas14
PublicaciónJournal of Attention Disorders
Volumen26
N.º13
DOI
EstadoPublicada - nov 2022

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