Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Camila A. Picchio; Sabela Lens; Manuel Hernandez-Guerra; Juan Arenas; Raul J. Andrade; Javier Crespo; Javier Garcia-Samaniego; Manuel Romero-Gomez; Juan Turnes; Jose Luis Calleja; Miguel Angel Simon; Trenton M. White; Mar Riveiro-Barciela; Anna Pocurull; Dalia Morales-Arraez; Alexandra Gomez; Maria Buti; Jeffrey Lazarus

doi:10.1038/s41598-021-01885-0

Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

Camila A. Picchio, Sabela Lens, Manuel Hernandez-Guerra, Juan Arenas, Raul J. Andrade, Javier Crespo, Javier Garcia-Samaniego, Manuel Romero-Gomez, Juan Turnes, Jose Luis Calleja, Miguel Angel Simon, Trenton M. White, Mar Riveiro-Barciela, Anna Pocurull, Dalia Morales-Arraez, Alexandra Gomez, Maria Buti, Jeffrey Lazarus

Departamento de Medicina

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

17 Citas (Scopus)

Resumen

Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate
treatment after significant disease progression face increased risk of severe liver complications
and death. Data are scarce on the characteristics and risk factors of people who present late to
care in Spain and globally. Data were collected from January 2018 to December 2019 to report
late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related
risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients
were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported
LP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male
(p < 0.001), being Spanish‑born (p < 0.001), and having an unknown origin of referral (p = 0.08) were
associated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patients
and late‑stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitis
specialist care is frequent in Spain, despite being a country with unrestricted treatment access.
Initiatives to reduce LP should specifically target men, older individuals, foreign‑born populations for
CHB, and Spanish nationals for CHC

Idioma original	Inglés
Número de artículo	24133
Páginas (desde-hasta)	1-12
Número de páginas	12
Publicación	SCIENTIFIC REPORTS
Volumen	11
N.º	1
DOI	https://doi.org/10.1038/s41598-021-01885-0
Estado	Publicada - 17 dic 2021

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10.1038/s41598-021-01885-0

https://ddd.uab.cat/record/292296

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Picchio, C. A., Lens, S., Hernandez-Guerra, M., Arenas, J., Andrade, R. J., Crespo, J., Garcia-Samaniego, J., Romero-Gomez, M., Turnes, J., Luis Calleja, J., Angel Simon, M., White, T. M., Riveiro-Barciela, M., Pocurull, A., Morales-Arraez, D., Gomez, A., Buti, M., & Lazarus, J. (2021). Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review. SCIENTIFIC REPORTS, 11(1), 1-12. Artículo 24133 . https://doi.org/10.1038/s41598-021-01885-0

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title = "Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review",

abstract = "Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiatetreatment after significant disease progression face increased risk of severe liver complicationsand death. Data are scarce on the characteristics and risk factors of people who present late tocare in Spain and globally. Data were collected from January 2018 to December 2019 to reportlate presentation (LP) to specialist care at 11 large university hospitals in Spain to assess relatedrisk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patientswere analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reportedLP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male(p < 0.001), being Spanish‑born (p < 0.001), and having an unknown origin of referral (p = 0.08) wereassociated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patientsand late‑stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitisspecialist care is frequent in Spain, despite being a country with unrestricted treatment access.Initiatives to reduce LP should specifically target men, older individuals, foreign‑born populations forCHB, and Spanish nationals for CHC",

author = "Picchio, {Camila A.} and Sabela Lens and Manuel Hernandez-Guerra and Juan Arenas and Andrade, {Raul J.} and Javier Crespo and Javier Garcia-Samaniego and Manuel Romero-Gomez and Juan Turnes and {Luis Calleja}, Jose and {Angel Simon}, Miguel and White, {Trenton M.} and Mar Riveiro-Barciela and Anna Pocurull and Dalia Morales-Arraez and Alexandra Gomez and Maria Buti and Jeffrey Lazarus",

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Picchio, CA, Lens, S, Hernandez-Guerra, M, Arenas, J, Andrade, RJ, Crespo, J, Garcia-Samaniego, J, Romero-Gomez, M, Turnes, J, Luis Calleja, J, Angel Simon, M, White, TM, Riveiro-Barciela, M, Pocurull, A, Morales-Arraez, D, Gomez, A, Buti, M & Lazarus, J 2021, 'Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review', SCIENTIFIC REPORTS, vol. 11, n.º 1, 24133 , pp. 1-12. https://doi.org/10.1038/s41598-021-01885-0

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T1 - Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review

AU - Picchio, Camila A.

AU - Lens, Sabela

AU - Hernandez-Guerra, Manuel

AU - Arenas, Juan

AU - Andrade, Raul J.

AU - Crespo, Javier

AU - Garcia-Samaniego, Javier

AU - Romero-Gomez, Manuel

AU - Turnes, Juan

AU - Luis Calleja, Jose

AU - Angel Simon, Miguel

AU - White, Trenton M.

AU - Riveiro-Barciela, Mar

AU - Pocurull, Anna

AU - Morales-Arraez, Dalia

AU - Gomez, Alexandra

AU - Buti, Maria

AU - Lazarus, Jeffrey

PY - 2021/12/17

Y1 - 2021/12/17

N2 - Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiatetreatment after significant disease progression face increased risk of severe liver complicationsand death. Data are scarce on the characteristics and risk factors of people who present late tocare in Spain and globally. Data were collected from January 2018 to December 2019 to reportlate presentation (LP) to specialist care at 11 large university hospitals in Spain to assess relatedrisk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patientswere analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reportedLP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male(p < 0.001), being Spanish‑born (p < 0.001), and having an unknown origin of referral (p = 0.08) wereassociated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patientsand late‑stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitisspecialist care is frequent in Spain, despite being a country with unrestricted treatment access.Initiatives to reduce LP should specifically target men, older individuals, foreign‑born populations forCHB, and Spanish nationals for CHC

AB - Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiatetreatment after significant disease progression face increased risk of severe liver complicationsand death. Data are scarce on the characteristics and risk factors of people who present late tocare in Spain and globally. Data were collected from January 2018 to December 2019 to reportlate presentation (LP) to specialist care at 11 large university hospitals in Spain to assess relatedrisk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patientswere analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reportedLP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male(p < 0.001), being Spanish‑born (p < 0.001), and having an unknown origin of referral (p = 0.08) wereassociated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patientsand late‑stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitisspecialist care is frequent in Spain, despite being a country with unrestricted treatment access.Initiatives to reduce LP should specifically target men, older individuals, foreign‑born populations forCHB, and Spanish nationals for CHC

U2 - 10.1038/s41598-021-01885-0

DO - 10.1038/s41598-021-01885-0

M3 - Article

SN - 2045-2322

VL - 11

SP - 1

EP - 12

JO - SCIENTIFIC REPORTS

JF - SCIENTIFIC REPORTS

IS - 1

M1 - 24133

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