TY - JOUR
T1 - Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?
AU - Ballesteros, Alejandro
AU - Sánchez-Torres, Ana M.
AU - López-Ilundain, Jose M.
AU - Cabrera, Bibiana
AU - Lobo, Antonio
AU - González-Pinto, Ana M.
AU - Díaz-Caneja, Covadonga
AU - Corripio, Iluminada
AU - Vieta, Eduard
AU - De La Serna, Elena
AU - Bobes, Julio
AU - Usall, Judith
AU - Contreras, Fernando
AU - Lorente-Omeñaca, Ruth
AU - Mezquida, Gisela
AU - Bernardo, Miguel
AU - Cuesta, Manuel J.
AU - Bioque, Miquel
AU - Amoretti, Silvia
AU - Parellada, Mara
AU - Vicente, Raquel
AU - Alonso, Anna
AU - Rabella, Mireia
AU - Gonzalez-Ortega, Itxaso
AU - Vega, Patricia
AU - Arbej, Julio
AU - Fayed, Nicolas
AU - Sanjuan, Julio
AU - Lorente-Rovira, Esther
AU - Berge, Daniel
AU - Bulbena, Antoni
AU - Hidalgo-Mazzei, Diego
AU - Garriga, Marina
AU - Baeza, Immaculada
AU - Castro-Fornieles, Josefina
AU - Albacete, Auria
AU - Menchon, Jose Manuel
AU - Garcia-Portilla, Mapaz P.
AU - Garciaalvarez, Leticia
AU - Gutierrrez, Miguel
AU - Zabala, Aranzazu
AU - Rodriguez-Jimenez, Roberto
AU - Morales-Munoz, Isabel
AU - Butjosa, Anna
AU - Pardo-Gallego, Marta
AU - Sarro, Salvador
AU - Landin-Moreno, Ramon
AU - Ibanez, Angela
AU - Moreno-Izco, Lucia
AU - Balanza-Martinez, Vicente
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Copyright © Cambridge University Press 2018. Background Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups.Methods Two hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinergic load of AP [in chlorpromazine equivalents (Eq-CPZ) and the Anticholinergic Risk Scale (ARS), respectively].Results Impairments in processing speed, verbal memory and global cognition were significantly associated with high Eq-CPZ and verbal impairment with high ARS score. Moreover, this effect was higher in the low IQ subgroup.Conclusions Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.
AB - Copyright © Cambridge University Press 2018. Background Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups.Methods Two hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinergic load of AP [in chlorpromazine equivalents (Eq-CPZ) and the Anticholinergic Risk Scale (ARS), respectively].Results Impairments in processing speed, verbal memory and global cognition were significantly associated with high Eq-CPZ and verbal impairment with high ARS score. Moreover, this effect was higher in the low IQ subgroup.Conclusions Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.
KW - Anticholinergic
KW - antipsychotics
KW - cognition
KW - first episode psychosis
KW - premorbid intellectual quotient.
U2 - 10.1017/S0033291717003774
DO - 10.1017/S0033291717003774
M3 - Article
C2 - 29331153
SN - 0033-2917
VL - 48
SP - 2247
EP - 2256
JO - Psychological Medicine
JF - Psychological Medicine
ER -