Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

Xiaoman Mao, Pilar Calero-Perez, David Montpeyó, Jordi Bruna, Victor J. Yuste, Ana Paula Candiota, Julia Lorenzo, Fernando Novio, Daniel Ruiz-Molina

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

7 Citas (Scopus)

Resumen

Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH-and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment.

Idioma originalInglés
Número de artículo1221
PublicaciónNanomaterials
Volumen12
N.º7
DOI
EstadoPublicada - 5 abr 2022

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