TY - JOUR
T1 - In situ Generation of Hypervalent Iodine Reagents for the Electrophilic Chlorination of Arenes
AU - Granados, Albert
AU - Jia, Zhiyu
AU - del Olmo, Marc
AU - Vallribera, Adelina
PY - 2019/5/8
Y1 - 2019/5/8
N2 - © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Efficient metal-free methods for the electrophilic chlorination of arenes using PIFA and simple chlorine sources are reported. The in situ formation of PhI(Cl)OCOCF 3 from PIFA and KCl is proposed, which resulted in a chlorinating species for moderately activated arenes. Moreover, the in situ formation of PhICl 2 from PIFA and TMSCl resulted in an excellent approach for the chlorination of a great variety of arenes (20 examples) in high yields, even when working on a multigram scale.
AB - © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Efficient metal-free methods for the electrophilic chlorination of arenes using PIFA and simple chlorine sources are reported. The in situ formation of PhI(Cl)OCOCF 3 from PIFA and KCl is proposed, which resulted in a chlorinating species for moderately activated arenes. Moreover, the in situ formation of PhICl 2 from PIFA and TMSCl resulted in an excellent approach for the chlorination of a great variety of arenes (20 examples) in high yields, even when working on a multigram scale.
KW - Arenes
KW - Electrophilic chlorination
KW - I(III) species
KW - PIFA
KW - TMSCl
UR - http://www.mendeley.com/research/situ-generation-hypervalent-iodine-reagents-electrophilic-chlorination-arenes
U2 - 10.1002/ejoc.201900237
DO - 10.1002/ejoc.201900237
M3 - Article
SN - 1434-193X
VL - 2019
SP - 2812
EP - 2818
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
ER -