Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling

Josep Saurí; Teodor Parella; R. Thomas Williamson; Gary E. Martin

doi:10.1002/mrc.4322

Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling

Josep Saurí, Teodor Parella, R. Thomas Williamson, Gary E. Martin^*

^*Autor correspondiente de este trabajo

Merck Sharp and Dohme (MSD)

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

20 Citas (Scopus)

Resumen

Homonuclear ¹³C–¹³C couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F₁ digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of ¹J_CC and ⁿJ_CC homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both ¹J_CC and ⁿJ_CC homonuclear ¹³C–¹³C coupling constants using ibuprofen as a model compound.

Idioma original	Inglés
Páginas (desde-hasta)	191-197
Número de páginas	7
Publicación	Magnetic Resonance in Chemistry
Volumen	55
N.º	3
DOI	https://doi.org/10.1002/mrc.4322
Estado	Publicada - 1 mar 2017

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Data: Improving the Performance of J-modulated ADEQUATE Experiments Through Homonuclear Decoupling and Non-Uniform Sampling
Saurí, J. (Creador), Parella, T. (Colaborador), Williamson, R. T. (Colaborador) & Martin, G. E. (Colaborador), 14 jul 2016
DOI: 10.6084/m9.figshare.1575703.v2, https://wiley.figshare.com/articles/dataset/Improving_the_Performance_of_J_modulated_ADEQUATE_Experiments_Through_Homonuclear_Decoupling_and_Non_Uniform_Sampling/1575703/2
Dataset: Conjunto de datos
Data: Improving the Performance of J-modulated ADEQUATE Experiments Through Homonuclear Decoupling and Non-Uniform Sampling
Saurí, J. (Creador), Parella, T. (Colaborador), Williamson, R. T. (Colaborador) & Martin, G. E. (Colaborador), figshare, 14 jul 2016
DOI: 10.6084/m9.figshare.1575703, https://figshare.com/articles/Improving_the_Performance_of_J_modulated_ADEQUATE_Experiments_Through_Homonuclear_Decoupling_and_Non_Uniform_Sampling/1575703
Dataset: Conjunto de datos

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title = "Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling",

abstract = "Homonuclear 13C–13C couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F1 digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of 1JCC and nJCC homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both 1JCC and nJCC homonuclear 13C–13C coupling constants using ibuprofen as a model compound.",

keywords = "C–C homonuclear coupling constants, ADEQUATE, broadband homonuclear decoupling, J-modulated ADEQUATE, non-uniform sampling (NUS)",

author = "Josep Saur{\'i} and Teodor Parella and Williamson, \{R. Thomas\} and Martin, \{Gary E.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2015 John Wiley \& Sons, Ltd.",

year = "2017",

month = mar,

day = "1",

doi = "10.1002/mrc.4322",

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AU - Saurí, Josep

AU - Parella, Teodor

AU - Williamson, R. Thomas

AU - Martin, Gary E.

PY - 2017/3/1

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AB - Homonuclear 13C–13C couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F1 digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of 1JCC and nJCC homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both 1JCC and nJCC homonuclear 13C–13C coupling constants using ibuprofen as a model compound.

KW - C–C homonuclear coupling constants

KW - ADEQUATE

KW - broadband homonuclear decoupling

KW - J-modulated ADEQUATE

KW - non-uniform sampling (NUS)

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DO - 10.1002/mrc.4322

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Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling

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Data: Improving the Performance of J-modulated ADEQUATE Experiments Through Homonuclear Decoupling and Non-Uniform Sampling

Data: Improving the Performance of J-modulated ADEQUATE Experiments Through Homonuclear Decoupling and Non-Uniform Sampling

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