HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules

Marta Catálfamo, Laurence Serradell, Carme Roura-Mir, Edgardo Kolkowski, Mireia Sospedra, Marta Vives-Pi, Francesca Vargas-Nieto, Ricardo Pujol-Borrell, Dolores Jaraquemada

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

17 Citas (Scopus)

Resumen

Thyroid follicular cells (TFC) in Graves' disease (GD) hyperexpress HLA class I and express ectopic HLA class II molecules, probably as a consequence of cytokines produced by infiltrating T cells. This finding led us to postulate that TFC could act as antigen-presenting cells, and in this way be responsible for the induction and/or maintenance of the in situ autoimmune T cell response. Invariant chain (li) and HLA-DM molecules are implicated in the antigen processing and presentation by HLA class II molecules. We have investigated the expression of these molecules by TFC from GD glands. The results demonstrate that class II+ TFC from GD patients also express li and HLA-DM, and this expression is increased after IFN-γ stimulation. The level of HLA-DM expression by TFC was low but sufficient to catalyze peptide loading into the HLA class II molecules and form stable HLA class II-peptide complexes expressed at the surface of TFC. These results have implications for the understanding of the possible role of HLA class Il+ TFC in thyroid autoimmune disease.
Idioma originalInglés
Páginas (desde-hasta)269-277
Número de páginas9
PublicaciónInternational Immunology
Volumen11
N.º2
DOI
EstadoPublicada - 17 feb 1999

Huella

Profundice en los temas de investigación de 'HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules'. En conjunto forman una huella única.

Citar esto