HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

Ester Ballana; Eva Riveira-Munoz; Christian Pou; Vanessa Bach; Mariona Parera; Marc Noguera; José R. Santos; Roger Badia; Maria Casadellà; Bonaventura Clotet; Roger Paredes; Miguel Angel Martínez; Christian Brander; José A. Esté

doi:10.1016/j.imbio.2012.06.012

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

Ester Ballana, Eva Riveira-Munoz, Christian Pou, Vanessa Bach, Mariona Parera, Marc Noguera, José R. Santos, Roger Badia, Maria Casadellà, Bonaventura Clotet, Roger Paredes, Miguel Angel Martínez, Christian Brander, José A. Esté

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Resumen

Homozygosity for a 32. bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment. © 2012 Elsevier GmbH.

Idioma original	Inglés
Páginas (desde-hasta)	543-547
Publicación	Immunobiology
Volumen	218
N.º	4
DOI	https://doi.org/10.1016/j.imbio.2012.06.012
Estado	Publicada - 1 abr 2013

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@article{653e1a9ca06b42ae99b77055c738d22d,

title = "HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32",

abstract = "Homozygosity for a 32. bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment. {\textcopyright} 2012 Elsevier GmbH.",

keywords = "CCR5-Δ32, Disease progression, HLA, Treatment outcome",

author = "Ester Ballana and Eva Riveira-Munoz and Christian Pou and Vanessa Bach and Mariona Parera and Marc Noguera and Santos, {Jos{\'e} R.} and Roger Badia and Maria Casadell{\`a} and Bonaventura Clotet and Roger Paredes and Mart{\'i}nez, {Miguel Angel} and Christian Brander and Est{\'e}, {Jos{\'e} A.}",

year = "2013",

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day = "1",

doi = "10.1016/j.imbio.2012.06.012",

language = "English",

volume = "218",

pages = "543--547",

journal = "Immunobiology",

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T1 - HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

AU - Ballana, Ester

AU - Riveira-Munoz, Eva

AU - Pou, Christian

AU - Bach, Vanessa

AU - Parera, Mariona

AU - Noguera, Marc

AU - Santos, José R.

AU - Badia, Roger

AU - Casadellà, Maria

AU - Clotet, Bonaventura

AU - Paredes, Roger

AU - Martínez, Miguel Angel

AU - Brander, Christian

AU - Esté, José A.

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Homozygosity for a 32. bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment. © 2012 Elsevier GmbH.

AB - Homozygosity for a 32. bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment. © 2012 Elsevier GmbH.

KW - CCR5-Δ32

KW - Disease progression

KW - HLA

KW - Treatment outcome

U2 - 10.1016/j.imbio.2012.06.012

DO - 10.1016/j.imbio.2012.06.012

M3 - Article

SN - 0171-2985

VL - 218

SP - 543

EP - 547

JO - Immunobiology

JF - Immunobiology

IS - 4

ER -

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

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