TY - JOUR
T1 - HDV evolution—will viral resistance be an issue in HDV infection?
AU - Tabernero, David
AU - Cortese, Maria Francesca
AU - Buti, Maria
AU - Rodriguez-Frias, Francisco
PY - 2018/10/1
Y1 - 2018/10/1
N2 - © 2018 Elsevier B.V. Hepatitis D virus (HDV) is a hepatotropic subviral infectious agent, obligate satellite of the Hepatitis B virus (HBV) and is highly related to viroids. HDV affects around 5% of the 257 million chronic HBV-carriers worldwide, leading to the most severe form of chronic viral hepatitis. Interferon alpha is the only approved treatment for chronic hepatitis D, albeit with low response rates (around 20%–30%). New antiviral strategies are currently under study. Due to the high viral evolution rates (10−3 to 10−4 substitutions/site/year) HDV forms an extremely complex viral population (quasispecies) that can be studied by Next-Generation Sequencing. Therefore, although specific viral resistance in HDV infection has not been reported, it cannot be completely discarded.
AB - © 2018 Elsevier B.V. Hepatitis D virus (HDV) is a hepatotropic subviral infectious agent, obligate satellite of the Hepatitis B virus (HBV) and is highly related to viroids. HDV affects around 5% of the 257 million chronic HBV-carriers worldwide, leading to the most severe form of chronic viral hepatitis. Interferon alpha is the only approved treatment for chronic hepatitis D, albeit with low response rates (around 20%–30%). New antiviral strategies are currently under study. Due to the high viral evolution rates (10−3 to 10−4 substitutions/site/year) HDV forms an extremely complex viral population (quasispecies) that can be studied by Next-Generation Sequencing. Therefore, although specific viral resistance in HDV infection has not been reported, it cannot be completely discarded.
U2 - 10.1016/j.coviro.2018.10.003
DO - 10.1016/j.coviro.2018.10.003
M3 - Review article
C2 - 30415162
SN - 1879-6257
VL - 32
SP - 100
EP - 107
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -