TY - JOUR
T1 - Genomic analysis of european drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses
AU - Kapun, Martin
AU - Barron, Maite G.
AU - Staubach, Fabian
AU - Obbard, Darren J.
AU - Axel, R.
AU - Vieira, Jorge
AU - Goubert, Clement
AU - Rota-Stabelli, Omar
AU - Kankare, Maaria
AU - Bogaerts-Marquez, Maria
AU - Haudry, Annabelle
AU - Waidele, Lena
AU - Kozeretska, Iryna
AU - Pasyukova, Elena G.
AU - Loeschcke, Volker
AU - Pascual, Marta
AU - Vieira, Cristina P.
AU - Serga, Svitlana
AU - Montchamp-Moreau, Catherine
AU - Abbott, Jessica
AU - Gibert, Patricia
AU - Porcelli, Damiano
AU - Posnien, Nico
AU - Sanchez-Gracia, Alejandro
AU - Grath, Sonja
AU - Sucena, Elio
AU - Bergland, Alan O.
AU - Guerreiro, Maria Pilar Garcia
AU - Onder, Banu Sebnem
AU - Argyridou, Eliza
AU - Guio, Lain
AU - Schou, Mads Fristrup
AU - Deplancke, Bart
AU - Vieira, Cristina
AU - Ritchie, Michael G.
AU - Zwaan, Bas J.
AU - Tauber, Eran
AU - Orengo, Dorcas J.
AU - Puerma, Eva
AU - Aguade, Montserrat
AU - Schmidt, Paul
AU - Parsch, John
AU - Betancourt, Andrea J.
AU - Flatt, Thomas
AU - Gonzalez, Josefa
N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. We also characterize variation among populations in the composition of the fly microbiome, and identify five new DNA viruses in our samples.
AB - Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. We also characterize variation among populations in the composition of the fly microbiome, and identify five new DNA viruses in our samples.
KW - Adaptation
KW - Clines
KW - Demography
KW - Population genomics
KW - Selection
KW - SNPs
KW - Structural variants
UR - http://www.scopus.com/inward/record.url?scp=85090025034&partnerID=8YFLogxK
U2 - 10.1093/molbev/msaa120
DO - 10.1093/molbev/msaa120
M3 - Article
C2 - 32413142
AN - SCOPUS:85090025034
SN - 0737-4038
VL - 37
SP - 2661
EP - 2678
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 9
ER -
