Genomewide Association Study of Severe Covid-19 with Respiratory Failure

David Ellinghaus; Frauke Degenhardt; Luis Bujanda; Maria Buti; Agustin Albillos; Pietro Invernizzi; Javier Fernandez; Daniele Prati; Guido Baselli; Rosanna Asselta; Marit M. Grimsrud; Chiara Milani; Fatima Aziz; Jan Kassens; Sandra May; Mareike Wendorff; Lars Wienbrandt; Florian Uellendahl-Werth; Tenghao Zheng; Xiaoli Yi; Raul de Pablo; Adolfo G. Chercoles; Adriana Palom; Alba-Estela Garcia-Fernandez; Francisco Rodriguez-Frias; Alberto Zanella; Alessandra Bandera; Alessandro Protti; Alessio Aghemo; Ana Lleo; Andrea Biondi; Andrea Caballero-Garralda; Andrea Gori; Anja Tanck; Anna Carreras Nolla; Anna Latiano; Anna Ludovica Fracanzani; Anna Peschuck; Antonio Julia; Antonio Pesenti; Antonio Voza; David Jimenez; Beatriz Mateos; Beatriz Nafria Jimenez; Carmen Quereda; Cinzia Paccapelo; Christoph Gassner; Claudio Angelini; Cristina Cea; Aurora Solier; David Pestana; Eduardo Muniz-Diaz; Elena Sandoval; Elvezia M. Paraboschi; Enrique Navas; Felix Garcia Sanchez; Ferruccio Ceriotti; Filippo Martinelli-Boneschi; Flora Peyvandi; Francesco Blasi; Luis Tellez; Albert Blanco-Grau; Georg Hemmrich-Stanisak; Giacomo Grasselli; Giorgio Costantino; Giulia Cardamone; Giuseppe Foti; Serena Aneli; Hayato Kurihara; Hesham ElAbd; Ilaria My; Ivan Galvan-Femenia; Javier Martin; Jeanette Erdmann; Jose Ferrusquia-Acosta; Koldo Garcia-Etxebarria; Laura Izquierdo-Sanchez; Laura R. Bettini; Lauro Sumoy; Leonardo Terranova; Leticia Moreira; Luigi Santoro; Luigia Scudeller; Francisco Mesonero; Luisa Roade; Malte C. Ruhlemann; Marco Schaefer; Maria Carrabba; Mar Riveiro-Barciela; Maria E. Figuera Basso; Maria G. Valsecchi; Maria Hernandez-Tejero; Marialbert Acosta-Herrera; Mariella D'Angio; Marina Baldini; Marina Cazzaniga; Martin Schulzky; Maurizio Cecconi; Michael Wittig; Michele Ciccarelli; Miguel Rodriguez-Gandia; Monica Bocciolone; Monica Miozzo; Nicola Montano; Nicole Braun; Nicoletta Sacchi; Nilda Martinez; Onur Ozer; Orazio Palmieri; Paola Faverio; Paoletta Preatoni; Paolo Bonfanti; Paolo Omodei; Paolo Tentorio; Pedro M. Rodrigues; Aaron Blandino; Rafael de Cid; Ricard Ferrer; Roberta Gualtierotti; Rosa Nieto; Siegfried Goerg; Salvatore Badalamenti; Sara Marsal; Giuseppe Matullo; Serena Pelusi; Simonas Juzenas; Stefano Aliberti; Valter Monzani; Victor Moreno; Tanja Wesse; Tobias L. Lenz; Tomas Pumarola; Valeria Rimoldi; Silvano Bosari; Wolfgang Albrecht; Wolfgang Peter; Manuel Romero-Gomez; Mauro D'Amato; Stefano Duga; Jesus M. Banales; Johannes R. Hov; Trine Folseraas; Luca Valenti; Andre Franke; Tom H. Karlsen; Severe Covid-19 GWAS Grp

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

David Ellinghaus, Frauke Degenhardt, Luis Bujanda, Maria Buti, Agustin Albillos, Pietro Invernizzi, Javier Fernandez, Daniele Prati, Guido Baselli, Rosanna Asselta, Marit M. Grimsrud, Chiara Milani, Fatima Aziz, Jan Kassens, Sandra May, Mareike Wendorff, Lars Wienbrandt, Florian Uellendahl-Werth, Tenghao Zheng, Xiaoli YiRaul de Pablo, Adolfo G. Chercoles, Adriana Palom, Alba-Estela Garcia-Fernandez, Francisco Rodriguez-Frias, Alberto Zanella, Alessandra Bandera, Alessandro Protti, Alessio Aghemo, Ana Lleo, Andrea Biondi, Andrea Caballero-Garralda, Andrea Gori, Anja Tanck, Anna Carreras Nolla, Anna Latiano, Anna Ludovica Fracanzani, Anna Peschuck, Antonio Julia, Antonio Pesenti, Antonio Voza, David Jimenez, Beatriz Mateos, Beatriz Nafria Jimenez, Carmen Quereda, Cinzia Paccapelo, Christoph Gassner, Claudio Angelini, Cristina Cea, Aurora Solier, David Pestana, Eduardo Muniz-Diaz, Elena Sandoval, Elvezia M. Paraboschi, Enrique Navas, Felix Garcia Sanchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Francesco Blasi, Luis Tellez, Albert Blanco-Grau, Georg Hemmrich-Stanisak, Giacomo Grasselli, Giorgio Costantino, Giulia Cardamone, Giuseppe Foti, Serena Aneli, Hayato Kurihara, Hesham ElAbd, Ilaria My, Ivan Galvan-Femenia, Javier Martin, Jeanette Erdmann, Jose Ferrusquia-Acosta, Koldo Garcia-Etxebarria, Laura Izquierdo-Sanchez, Laura R. Bettini, Lauro Sumoy, Leonardo Terranova, Leticia Moreira, Luigi Santoro, Luigia Scudeller, Francisco Mesonero, Luisa Roade, Malte C. Ruhlemann, Marco Schaefer, Maria Carrabba, Mar Riveiro-Barciela, Maria E. Figuera Basso, Maria G. Valsecchi, Maria Hernandez-Tejero, Marialbert Acosta-Herrera, Mariella D'Angio, Marina Baldini, Marina Cazzaniga, Martin Schulzky, Maurizio Cecconi, Michael Wittig, Michele Ciccarelli, Miguel Rodriguez-Gandia, Monica Bocciolone, Monica Miozzo, Nicola Montano, Nicole Braun, Nicoletta Sacchi, Nilda Martinez, Onur Ozer, Orazio Palmieri, Paola Faverio, Paoletta Preatoni, Paolo Bonfanti, Paolo Omodei, Paolo Tentorio, Pedro M. Rodrigues, Aaron Blandino, Rafael de Cid, Ricard Ferrer, Roberta Gualtierotti, Rosa Nieto, Siegfried Goerg, Salvatore Badalamenti, Sara Marsal, Giuseppe Matullo, Serena Pelusi, Simonas Juzenas, Stefano Aliberti, Valter Monzani, Victor Moreno, Tanja Wesse, Tobias L. Lenz, Tomas Pumarola, Valeria Rimoldi, Silvano Bosari, Wolfgang Albrecht, Wolfgang Peter, Manuel Romero-Gomez, Mauro D'Amato, Stefano Duga, Jesus M. Banales, Johannes R. Hov, Trine Folseraas, Luca Valenti, Andre Franke, Tom H. Karlsen, Severe Covid-19 GWAS Grp

Producción científica: Contribución a una revista › Artículo › Investigación › revisión exhaustiva

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Resumen

BACKGROUND There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels. RESULTS We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P

Idioma original	Español
Páginas (desde-hasta)	1522-1534
Número de páginas	13
Publicación	New England Journal of Medicine
Volumen	383
N.º	16
Estado	Publicada - 15 oct 2020

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Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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https://www.scopus.com/pages/publications/85087699779

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Ellinghaus, D., Degenhardt, F., Bujanda, L., Buti, M., Albillos, A., Invernizzi, P., Fernandez, J., Prati, D., Baselli, G., Asselta, R., Grimsrud, M. M., Milani, C., Aziz, F., Kassens, J., May, S., Wendorff, M., Wienbrandt, L., Uellendahl-Werth, F., Zheng, T., ... Grp, S. C. GWAS. (2020). Genomewide Association Study of Severe Covid-19 with Respiratory Failure. New England Journal of Medicine, 383(16), 1522-1534.

@article{2f0ead39f581450fb7a440ef2fa9d8be,

title = "Genomewide Association Study of Severe Covid-19 with Respiratory Failure",

abstract = "BACKGROUND There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels. RESULTS We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P",

author = "David Ellinghaus and Frauke Degenhardt and Luis Bujanda and Maria Buti and Agustin Albillos and Pietro Invernizzi and Javier Fernandez and Daniele Prati and Guido Baselli and Rosanna Asselta and Grimsrud, \{Marit M.\} and Chiara Milani and Fatima Aziz and Jan Kassens and Sandra May and Mareike Wendorff and Lars Wienbrandt and Florian Uellendahl-Werth and Tenghao Zheng and Xiaoli Yi and \{de Pablo\}, Raul and Chercoles, \{Adolfo G.\} and Adriana Palom and Alba-Estela Garcia-Fernandez and Francisco Rodriguez-Frias and Alberto Zanella and Alessandra Bandera and Alessandro Protti and Alessio Aghemo and Ana Lleo and Andrea Biondi and Andrea Caballero-Garralda and Andrea Gori and Anja Tanck and Nolla, \{Anna Carreras\} and Anna Latiano and Fracanzani, \{Anna Ludovica\} and Anna Peschuck and Antonio Julia and Antonio Pesenti and Antonio Voza and David Jimenez and Beatriz Mateos and Jimenez, \{Beatriz Nafria\} and Carmen Quereda and Cinzia Paccapelo and Christoph Gassner and Claudio Angelini and Cristina Cea and Aurora Solier and David Pestana and Eduardo Muniz-Diaz and Elena Sandoval and Paraboschi, \{Elvezia M.\} and Enrique Navas and Sanchez, \{Felix Garcia\} and Ferruccio Ceriotti and Filippo Martinelli-Boneschi and Flora Peyvandi and Francesco Blasi and Luis Tellez and Albert Blanco-Grau and Georg Hemmrich-Stanisak and Giacomo Grasselli and Giorgio Costantino and Giulia Cardamone and Giuseppe Foti and Serena Aneli and Hayato Kurihara and Hesham ElAbd and Ilaria My and Ivan Galvan-Femenia and Javier Martin and Jeanette Erdmann and Jose Ferrusquia-Acosta and Koldo Garcia-Etxebarria and Laura Izquierdo-Sanchez and Bettini, \{Laura R.\} and Lauro Sumoy and Leonardo Terranova and Leticia Moreira and Luigi Santoro and Luigia Scudeller and Francisco Mesonero and Luisa Roade and Ruhlemann, \{Malte C.\} and Marco Schaefer and Maria Carrabba and Mar Riveiro-Barciela and Basso, \{Maria E. Figuera\} and Valsecchi, \{Maria G.\} and Maria Hernandez-Tejero and Marialbert Acosta-Herrera and Mariella D'Angio and Marina Baldini and Marina Cazzaniga and Martin Schulzky and Maurizio Cecconi and Michael Wittig and Michele Ciccarelli and Miguel Rodriguez-Gandia and Monica Bocciolone and Monica Miozzo and Nicola Montano and Nicole Braun and Nicoletta Sacchi and Nilda Martinez and Onur Ozer and Orazio Palmieri and Paola Faverio and Paoletta Preatoni and Paolo Bonfanti and Paolo Omodei and Paolo Tentorio and Rodrigues, \{Pedro M.\} and Aaron Blandino and \{de Cid\}, Rafael and Ricard Ferrer and Roberta Gualtierotti and Rosa Nieto and Siegfried Goerg and Salvatore Badalamenti and Sara Marsal and Giuseppe Matullo and Serena Pelusi and Simonas Juzenas and Stefano Aliberti and Valter Monzani and Victor Moreno and Tanja Wesse and Lenz, \{Tobias L.\} and Tomas Pumarola and Valeria Rimoldi and Silvano Bosari and Wolfgang Albrecht and Wolfgang Peter and Manuel Romero-Gomez and Mauro D'Amato and Stefano Duga and Banales, \{Jesus M.\} and Hov, \{Johannes R.\} and Trine Folseraas and Luca Valenti and Andre Franke and Karlsen, \{Tom H.\} and Grp, \{Severe Covid-19 GWAS\}",

note = " Copyright {\textcopyright} 2020 Massachusetts Medical Society.",

year = "2020",

month = oct,

day = "15",

language = "Espa{\~n}ol",

volume = "383",

pages = "1522--1534",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "16",

}

Ellinghaus, D, Degenhardt, F, Bujanda, L, Buti, M, Albillos, A, Invernizzi, P, Fernandez, J, Prati, D, Baselli, G, Asselta, R, Grimsrud, MM, Milani, C, Aziz, F, Kassens, J, May, S, Wendorff, M, Wienbrandt, L, Uellendahl-Werth, F, Zheng, T, Yi, X, de Pablo, R, Chercoles, AG, Palom, A, Garcia-Fernandez, A-E, Rodriguez-Frias, F, Zanella, A, Bandera, A, Protti, A, Aghemo, A, Lleo, A, Biondi, A, Caballero-Garralda, A, Gori, A, Tanck, A, Nolla, AC, Latiano, A, Fracanzani, AL, Peschuck, A, Julia, A, Pesenti, A, Voza, A, Jimenez, D, Mateos, B, Jimenez, BN, Quereda, C, Paccapelo, C, Gassner, C, Angelini, C, Cea, C, Solier, A, Pestana, D, Muniz-Diaz, E, Sandoval, E, Paraboschi, EM, Navas, E, Sanchez, FG, Ceriotti, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Tellez, L, Blanco-Grau, A, Hemmrich-Stanisak, G, Grasselli, G, Costantino, G, Cardamone, G, Foti, G, Aneli, S, Kurihara, H, ElAbd, H, My, I, Galvan-Femenia, I, Martin, J, Erdmann, J, Ferrusquia-Acosta, J, Garcia-Etxebarria, K, Izquierdo-Sanchez, L, Bettini, LR, Sumoy, L, Terranova, L, Moreira, L, Santoro, L, Scudeller, L, Mesonero, F, Roade, L, Ruhlemann, MC, Schaefer, M, Carrabba, M, Riveiro-Barciela, M, Basso, MEF, Valsecchi, MG, Hernandez-Tejero, M, Acosta-Herrera, M, D'Angio, M, Baldini, M, Cazzaniga, M, Schulzky, M, Cecconi, M, Wittig, M, Ciccarelli, M, Rodriguez-Gandia, M, Bocciolone, M, Miozzo, M, Montano, N, Braun, N, Sacchi, N, Martinez, N, Ozer, O, Palmieri, O, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Tentorio, P, Rodrigues, PM, Blandino, A, de Cid, R, Ferrer, R, Gualtierotti, R, Nieto, R, Goerg, S, Badalamenti, S, Marsal, S, Matullo, G, Pelusi, S, Juzenas, S, Aliberti, S, Monzani, V, Moreno, V, Wesse, T, Lenz, TL, Pumarola, T, Rimoldi, V, Bosari, S, Albrecht, W, Peter, W, Romero-Gomez, M, D'Amato, M, Duga, S, Banales, JM, Hov, JR, Folseraas, T, Valenti, L, Franke, A, Karlsen, TH & Grp, SCGWAS 2020, 'Genomewide Association Study of Severe Covid-19 with Respiratory Failure', New England Journal of Medicine, vol. 383, n.º 16, pp. 1522-1534.

TY - JOUR

T1 - Genomewide Association Study of Severe Covid-19 with Respiratory Failure

AU - Ellinghaus, David

AU - Degenhardt, Frauke

AU - Bujanda, Luis

AU - Buti, Maria

AU - Albillos, Agustin

AU - Invernizzi, Pietro

AU - Fernandez, Javier

AU - Prati, Daniele

AU - Baselli, Guido

AU - Asselta, Rosanna

AU - Grimsrud, Marit M.

AU - Milani, Chiara

AU - Aziz, Fatima

AU - Kassens, Jan

AU - May, Sandra

AU - Wendorff, Mareike

AU - Wienbrandt, Lars

AU - Uellendahl-Werth, Florian

AU - Zheng, Tenghao

AU - Yi, Xiaoli

AU - de Pablo, Raul

AU - Chercoles, Adolfo G.

AU - Palom, Adriana

AU - Garcia-Fernandez, Alba-Estela

AU - Rodriguez-Frias, Francisco

AU - Zanella, Alberto

AU - Bandera, Alessandra

AU - Protti, Alessandro

AU - Aghemo, Alessio

AU - Lleo, Ana

AU - Biondi, Andrea

AU - Caballero-Garralda, Andrea

AU - Gori, Andrea

AU - Tanck, Anja

AU - Nolla, Anna Carreras

AU - Latiano, Anna

AU - Fracanzani, Anna Ludovica

AU - Peschuck, Anna

AU - Julia, Antonio

AU - Pesenti, Antonio

AU - Voza, Antonio

AU - Jimenez, David

AU - Mateos, Beatriz

AU - Jimenez, Beatriz Nafria

AU - Quereda, Carmen

AU - Paccapelo, Cinzia

AU - Gassner, Christoph

AU - Angelini, Claudio

AU - Cea, Cristina

AU - Solier, Aurora

AU - Pestana, David

AU - Muniz-Diaz, Eduardo

AU - Sandoval, Elena

AU - Paraboschi, Elvezia M.

AU - Navas, Enrique

AU - Sanchez, Felix Garcia

AU - Ceriotti, Ferruccio

AU - Martinelli-Boneschi, Filippo

AU - Peyvandi, Flora

AU - Blasi, Francesco

AU - Tellez, Luis

AU - Blanco-Grau, Albert

AU - Hemmrich-Stanisak, Georg

AU - Grasselli, Giacomo

AU - Costantino, Giorgio

AU - Cardamone, Giulia

AU - Foti, Giuseppe

AU - Aneli, Serena

AU - Kurihara, Hayato

AU - ElAbd, Hesham

AU - My, Ilaria

AU - Galvan-Femenia, Ivan

AU - Martin, Javier

AU - Erdmann, Jeanette

AU - Ferrusquia-Acosta, Jose

AU - Garcia-Etxebarria, Koldo

AU - Izquierdo-Sanchez, Laura

AU - Bettini, Laura R.

AU - Sumoy, Lauro

AU - Terranova, Leonardo

AU - Moreira, Leticia

AU - Santoro, Luigi

AU - Scudeller, Luigia

AU - Mesonero, Francisco

AU - Roade, Luisa

AU - Ruhlemann, Malte C.

AU - Schaefer, Marco

AU - Carrabba, Maria

AU - Riveiro-Barciela, Mar

AU - Basso, Maria E. Figuera

AU - Valsecchi, Maria G.

AU - Hernandez-Tejero, Maria

AU - Acosta-Herrera, Marialbert

AU - D'Angio, Mariella

AU - Baldini, Marina

AU - Cazzaniga, Marina

AU - Schulzky, Martin

AU - Cecconi, Maurizio

AU - Wittig, Michael

AU - Ciccarelli, Michele

AU - Rodriguez-Gandia, Miguel

AU - Bocciolone, Monica

AU - Miozzo, Monica

AU - Montano, Nicola

AU - Braun, Nicole

AU - Sacchi, Nicoletta

AU - Martinez, Nilda

AU - Ozer, Onur

AU - Palmieri, Orazio

AU - Faverio, Paola

AU - Preatoni, Paoletta

AU - Bonfanti, Paolo

AU - Omodei, Paolo

AU - Tentorio, Paolo

AU - Rodrigues, Pedro M.

AU - Blandino, Aaron

AU - de Cid, Rafael

AU - Ferrer, Ricard

AU - Gualtierotti, Roberta

AU - Nieto, Rosa

AU - Goerg, Siegfried

AU - Badalamenti, Salvatore

AU - Marsal, Sara

AU - Matullo, Giuseppe

AU - Pelusi, Serena

AU - Juzenas, Simonas

AU - Aliberti, Stefano

AU - Monzani, Valter

AU - Moreno, Victor

AU - Wesse, Tanja

AU - Lenz, Tobias L.

AU - Pumarola, Tomas

AU - Rimoldi, Valeria

AU - Bosari, Silvano

AU - Albrecht, Wolfgang

AU - Peter, Wolfgang

AU - Romero-Gomez, Manuel

AU - D'Amato, Mauro

AU - Duga, Stefano

AU - Banales, Jesus M.

AU - Hov, Johannes R.

AU - Folseraas, Trine

AU - Valenti, Luca

AU - Franke, Andre

AU - Karlsen, Tom H.

AU - Grp, Severe Covid-19 GWAS

PY - 2020/10/15

Y1 - 2020/10/15

N2 - BACKGROUND There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels. RESULTS We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P

AB - BACKGROUND There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the final analysis. In total, we analyzed 8,582,968 single-nucleotide polymorphisms and conducted a meta-analysis of the two case–control panels. RESULTS We detected cross-replicating associations with rs11385942 at locus 3p21.31 and with rs657152 at locus 9q34.2, which were significant at the genomewide level (P

UR - https://www.scopus.com/pages/publications/85087699779

M3 - Artículo

SN - 0028-4793

VL - 383

SP - 1522

EP - 1534

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 16

ER -