TY - JOUR
T1 - Functional characterization of AbaQ, a novel efflux pump mediating quinolone resistance in acinetobacter baumannii
AU - Pérez-Varela, María
AU - Corral, Jordi
AU - Aranda, Jesús
AU - Barbé, Jordi
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Copyright © 2018 American Society for Microbiology. All Rights Reserved. Acinetobacter baumannii has emerged as an important multidrug-resistant nosocomial pathogen. In previous work, we identified a putative MFS transporter, AU097_RS17040, involved in the pathogenicity of A. baumannii (M. Pérez-Varela, J. Corral, J. A. Vallejo, S. Rumbo-Feal, G. Bou, J. Aranda, and J. Barbé, Infect Immun 85:e00327-17, 2017, https://doi.org/10.1128/IAI.00327-17). In this study, we analyzed the susceptibility to diverse antimicrobial agents of A. baumannii cells defective in this transporter, referred to as AbaQ. Our results showed that AbaQ is mainly involved in the extrusion of quinolone-type drugs in A. baumannii.
AB - Copyright © 2018 American Society for Microbiology. All Rights Reserved. Acinetobacter baumannii has emerged as an important multidrug-resistant nosocomial pathogen. In previous work, we identified a putative MFS transporter, AU097_RS17040, involved in the pathogenicity of A. baumannii (M. Pérez-Varela, J. Corral, J. A. Vallejo, S. Rumbo-Feal, G. Bou, J. Aranda, and J. Barbé, Infect Immun 85:e00327-17, 2017, https://doi.org/10.1128/IAI.00327-17). In this study, we analyzed the susceptibility to diverse antimicrobial agents of A. baumannii cells defective in this transporter, referred to as AbaQ. Our results showed that AbaQ is mainly involved in the extrusion of quinolone-type drugs in A. baumannii.
KW - Acinetobacter
KW - Efflux pumps
KW - Quinolones
U2 - 10.1128/AAC.00906-18
DO - 10.1128/AAC.00906-18
M3 - Article
SN - 0066-4804
VL - 62
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
M1 - e00906-18
ER -