TY - JOUR
T1 - Frequency of breast cancer with hereditary risk features in Spain :
T2 - Analysis from GEICAM "El Álamo III" retrospective study
AU - Márquez-Rodas, Iván
AU - Pollán, Marina
AU - Escudero, María José
AU - Ruiz, Amparo
AU - Martín Jiménez, Miguel
AU - Santaballa, Ana
AU - Martínez del Prado, Purificación
AU - Batista, Norberto
AU - Andrés Conejero, Raquel
AU - Antón, Antonio
AU - Llombart, Antonio
AU - Fernandez Aramburu, Antonio
AU - Adrover, Encarna
AU - González, Sonia
AU - Seguí, Miguel Angel
AU - Calvo Martínez, Lourdes
AU - Lizón, José
AU - Rodríguez Lescure, Álvaro
AU - Ramon y Cajal, Teresa
AU - Llort, Gemma
AU - Jara Sánchez, Carlos
AU - Carrasco, Eva
AU - López-Tarruella, Sara
PY - 2017
Y1 - 2017
N2 - To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain. A retrospective analysis was conducted from 10,638 BC patients diagnosed between 1998 and 2001 in the GEICAM registry "El Álamo III", dividing them into four groups according to modified ESMO and SEOM hereditary cancer risk criteria: Sporadic breast cancer group (R0); Individual risk group (IR); Familial risk group (FR); Individual and familial risk group (IFR) with both individual and familial risk criteria. 7,641 patients were evaluable. Of them, 2,252 patients (29.5%) had at least one hereditary risk criteria, being subclassified in: FR 1.105 (14.5%), IR 970 (12.7%), IFR 177 (2.3%). There was a higher frequency of newly diagnosed metastatic patients in the IR group (5.1% vs 3.2%, p = 0.02). In contrast, in RO were lower proportion of big tumors (
AB - To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain. A retrospective analysis was conducted from 10,638 BC patients diagnosed between 1998 and 2001 in the GEICAM registry "El Álamo III", dividing them into four groups according to modified ESMO and SEOM hereditary cancer risk criteria: Sporadic breast cancer group (R0); Individual risk group (IR); Familial risk group (FR); Individual and familial risk group (IFR) with both individual and familial risk criteria. 7,641 patients were evaluable. Of them, 2,252 patients (29.5%) had at least one hereditary risk criteria, being subclassified in: FR 1.105 (14.5%), IR 970 (12.7%), IFR 177 (2.3%). There was a higher frequency of newly diagnosed metastatic patients in the IR group (5.1% vs 3.2%, p = 0.02). In contrast, in RO were lower proportion of big tumors (
U2 - 10.1371/journal.pone.0184181
DO - 10.1371/journal.pone.0184181
M3 - Article
C2 - 28985233
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 10
ER -
