Fluorescent Markers for Amyloid-β Detection: Computational Insights

Francesca Peccati, Stefano Pantaleone, Xavier Solans-Monfort, Mariona Sodupe

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2 Citas (Scopus)

Resumen

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim In vivo detection of cerebral amyloid-β plaques is essential for an early diagnosis of Alzheimer′s disease. Optical imaging, which employs fluorescent markers emitting in the near-infrared range, is a growing alternative to nuclear techniques, with indisputable advantages. The rational design of amyloid markers requires optimization of both the optical and binding properties, and of their mutual interaction. In this work, the structural aspects that determine the performance of selected amyloid markers have been analyzed, focusing on the contributions offered by computational techniques.
Idioma originalInglés
Páginas (desde-hasta)686-698
PublicaciónIsrael Journal of Chemistry
Volumen57
N.º7
DOI
EstadoPublicada - 1 jul 2017

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