Finding MYCure

Marie Eve Beaulieu; Laura Soucek

doi:10.1080/23723556.2019.1618178

Finding MYCure

Marie Eve Beaulieu, Laura Soucek

Departamento de Bioquímica y Biología Molecular

Producción científica: Contribución a una revista › Artículo › Investigación

8 Citas (Scopus)

Resumen

Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine “Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy”, we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.

Idioma original	Inglés
Número de artículo	e1618178
Publicación	Molecular and Cellular Oncology
Volumen	6
N.º	5
DOI	https://doi.org/10.1080/23723556.2019.1618178
Estado	Publicada - 1 ene 2019

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title = "Finding MYCure",

abstract = "{\textcopyright} 2019, {\textcopyright} 2019 The Author(s). Published with license by Taylor \& Francis Group, LLC. Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine “Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy”, we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.",

keywords = "MYC, NSCLC, OMOMYC, mini-protein, peptide therapeutic",

author = "Beaulieu, \{Marie Eve\} and Laura Soucek",

year = "2019",

month = jan,

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doi = "10.1080/23723556.2019.1618178",

language = "English",

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AU - Beaulieu, Marie Eve

AU - Soucek, Laura

PY - 2019/1/1

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N2 - © 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine “Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy”, we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.

AB - © 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine “Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy”, we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.

KW - MYC

KW - NSCLC

KW - OMOMYC

KW - mini-protein

KW - peptide therapeutic

UR - http://www.mendeley.com/research/finding-mycure

UR - https://www.scopus.com/pages/publications/85068112352

U2 - 10.1080/23723556.2019.1618178

DO - 10.1080/23723556.2019.1618178

M3 - Article

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SN - 2372-3556

VL - 6

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 5

M1 - e1618178

ER -

Finding MYCure

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