Evaluation of previous substance dependence genome-wide significant findings in a Spanish sample

Laura Pineda-Cirera, Judit Cabana-Domínguez, Carlos Roncero, Mònica Cozar, Lara Grau-López, Alfonso C. Abad, Nieves Martínez-Luna, María Robles-Martínez, Cristina Sánchez-Mora, Josep Antoni Ramos-Quiroga, Miquel Casas, Marta Ribasés, Noèlia Fernàndez-Castillo, Bru Cormand

Producción científica: Contribución a una revistaArtículoInvestigaciónrevisión exhaustiva

3 Citas (Scopus)

Resumen

© 2018 Elsevier B.V. Background: Substance dependence is a chronic and relapsing disorder explained by genetic and environmental risk factors. The aim of our study is to replicate previous genome-wide significant (GWS) hits identified in substance dependence in general or in cocaine dependence in particular using an independent sample from Spain. Methods: We evaluated, in a Spanish sample of 1711 subjects with substance dependence (1011 of them cocaine dependent) and 1719 control individuals, three SNPs identified as GWS in previous studies: rs1868152 and rs2952621 (located near LINC02052 and LINC01854, respectively), associated with substance dependence, and rs2629540 (in the first intron of FAM53B), associated with cocaine dependence. Results: We replicated the association between rs2952621 and substance dependence under the dominant model (P = 0.020), with the risk allele (T) being the same in our sample and in those two reported previously. We then performed a meta-analysis of the two samples used in the original study that reported the association of rs2952621 with substance dependence (Collaborative Studies on Genetics of Alcoholism (COGA) and Study of Addiction: Genetics and Environment (SAGE)) together with our Spanish sample. The meta-analysis of 3747 cases and 4043 controls confirmed the association (OR = 1.26, 95% CI = 1.15–1.39). Conclusions: The rs2952621 variant, located downstream from the yet uncharacterized gene LINC01854, is associated with substance dependence in our Spanish sample. Further research is needed to understand its contribution to the susceptibility to substance dependence.
Idioma originalInglés
Páginas (desde-hasta)358-362
PublicaciónDrug and Alcohol Dependence
Volumen187
DOI
EstadoPublicada - 1 jun 2018

Huella

Profundice en los temas de investigación de 'Evaluation of previous substance dependence genome-wide significant findings in a Spanish sample'. En conjunto forman una huella única.

Citar esto